caa a22 4500 445356359 CHVBK 20180317142901.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10072-011-0521-8 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0521-8 Polytherapy for the prophylaxis of chronic migraine: an Italian survey [Elektronische Daten] [D. D'Amico, M. Curone, V. Tullo, A. Proietti Cecchini, E. Mea, G. Bussone] Chronic migraine (CM) represents an important medical issue, due to morbidity, high disability, presence of comorbidities, and medication overuse (MO). The prophylaxis of CM has not been extensively explored so far. Patients with CM are often treated with two or more compounds, although there is no clear evidence that polytherapy may be superior to monotherapy. We evaluated the percentage of prescription of polytherapy for the prophylaxis of CM in a clinical sample. We examined the charts of 98 CM patients admitted to our Headache Center for inpatient withdrawal program to stop MO. Results showed that only one drug for prophylaxis was prescribed in 20.4% cases, two or more drugs in 79.6%, with 63.3% of the total sample falling in the group "true polytherapy”, i.e. all the drugs prescribed on daily basis were given to treat CM, and not only to treat concomitant conditions. In more than 60% cases a combination of drugs indicated for migraine prophylaxis and drugs only indicated for other conditions (mainly for psychiatric disorders) was prescribed. Our survey indicates that polytherapy may be rather common in CM, and suggests that comorbidities may strongly influence treatment choices. Springer-Verlag, 2011 Chronic migraine (CM) nationallicence Medication overuse (MO) nationallicence Prophylaxis nationallicence Polytherapy nationallicence Comorbidity nationallicence D'Amico D. Headache Center, Neurological Institute "C. Besta” IRCCS Foundation, Milan, Italy aut Curone M. Headache Center, Neurological Institute "C. Besta” IRCCS Foundation, Milan, Italy aut Tullo V. Headache Center, Neurological Institute "C. Besta” IRCCS Foundation, Milan, Italy aut Proietti Cecchini A. Headache Center, Neurological Institute "C. Besta” IRCCS Foundation, Milan, Italy aut Mea E. Headache Center, Neurological Institute "C. Besta” IRCCS Foundation, Milan, Italy aut Bussone G. Headache Center, Neurological Institute "C. Besta” IRCCS Foundation, Milan, Italy aut Neurological Sciences Springer Milan 32(2011-05-01), 185-188 1590-1874 32<185 2011 32 10072 https://doi.org/10.1007/s10072-011-0521-8 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0521-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- D'Amico D. Headache Center, Neurological Institute "C. Besta” IRCCS Foundation, Milan, Italy aut NATIONALLICENCE 700 1- Curone M. Headache Center, Neurological Institute "C. Besta” IRCCS Foundation, Milan, Italy aut NATIONALLICENCE 700 1- Tullo V. Headache Center, Neurological Institute "C. Besta” IRCCS Foundation, Milan, Italy aut NATIONALLICENCE 700 1- Proietti Cecchini A. Headache Center, Neurological Institute "C. Besta” IRCCS Foundation, Milan, Italy aut NATIONALLICENCE 700 1- Mea E. Headache Center, Neurological Institute "C. Besta” IRCCS Foundation, Milan, Italy aut NATIONALLICENCE 700 1- Bussone G. Headache Center, Neurological Institute "C. Besta” IRCCS Foundation, Milan, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32(2011-05-01), 185-188 1590-1874 32<185 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer