caa a22 4500 445356421 CHVBK 20180317142901.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10072-011-0522-7 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0522-7 Gingkolide B as migraine preventive treatment in young age: results at 1-year follow-up [Elektronische Daten] [Susanna Usai, Licia Grazzi, Gennaro Bussone] Primary headaches, migraine and tension-type headaches are some of the most frequent conditions in young age. Even before pharmacological treatment, it is mainly useful in these patients to adopt an appropriate lifestyle, with regular sleep, meals, computer and TV, sport, and avoiding triggers. Any specific and effective pharmacological treatment for migraine and tension-type headache is never lacking in side effects. Gingkolide B, an herbal constituent extract from Ginko biloba tree leaves, is a natural anti platelet activating factor (PAF). PAF is a potent pro inflammatory and nociceptive agent released during the inflammation process. Therefore, Gingkolide B can be considered a promising non pharmacological tool for treatment of migraine with and without aura. In an earlier clinical report, we described our initial attempts to assess the clinical utility of Gingkolide B in a small group of young migraine patients. A small sample of 30 young patients suffering from migraine without aura entered the open-label prospective trial. Migraine without aura was diagnosed according to International Headache Society (IHS) criteria. The treatment was well tolerated and the compliance was good. Despite the uncontrolled open-label design of this study and the small sample of patients, these data show that Gingkolide B seems to be effective as preventive treatment in reducing migraine attack frequency and in attenuating the use of symptomatic medication in our small series of children with primary headache. The Author(s), 2011 Headache nationallicence Young age nationallicence Gingkolide B nationallicence Preventive treatment nationallicence Usai Susanna Department of Neurological Sciences, Headache Unit, Neurological Institute "C. Besta” IRCCS Foundation, Via Celoria, 11, 20133, Milan, Italy aut Grazzi Licia Department of Neurological Sciences, Headache Unit, Neurological Institute "C. Besta” IRCCS Foundation, Via Celoria, 11, 20133, Milan, Italy aut Bussone Gennaro Department of Neurological Sciences, Headache Unit, Neurological Institute "C. Besta” IRCCS Foundation, Via Celoria, 11, 20133, Milan, Italy aut Neurological Sciences Springer Milan 32(2011-05-01), 197-199 1590-1874 32<197 2011 32 10072 https://doi.org/10.1007/s10072-011-0522-7 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0522-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Usai Susanna Department of Neurological Sciences, Headache Unit, Neurological Institute "C. Besta” IRCCS Foundation, Via Celoria, 11, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Grazzi Licia Department of Neurological Sciences, Headache Unit, Neurological Institute "C. Besta” IRCCS Foundation, Via Celoria, 11, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Bussone Gennaro Department of Neurological Sciences, Headache Unit, Neurological Institute "C. Besta” IRCCS Foundation, Via Celoria, 11, 20133, Milan, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32(2011-05-01), 197-199 1590-1874 32<197 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer