caa a22 4500 445356553 CHVBK 20180317142902.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10072-011-0542-3 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0542-3 Rapoport A. David Geffen School of Medicine at UCLA, 239 South Orange Drive, 90036, Los Angeles, CA, USA aut New frontiers in headache therapy [Elektronische Daten] [A. Rapoport] There are numerous headache therapies available for our patients, more for migraine than for any of the other primary headache disorders. Only four medications have been approved for migraine prevention in the last few decades in the US and onabotulinumtoxinA was recently approved in the UK and the US for chronic migraine. We have been more fortunate in the acute care arena where in the US we have had seven triptans and one nonsteroidal anti-inflammatory medication approved by the FDA and currently available. There are several other acute care medications in various stages of development and there are two new methods of administering a triptan and others under investigation. We are always looking for faster, easier and more efficient administration of medications with fewer adverse events, as optimal migraine therapy requires these characteristics. What follows is a brief review of the progress in development for four of the many new acute care medications being investigated: the CGRP antagonist tablet telcagepant, the sumatriptan iontophoretic patch, sumatriptan powder for use in the OptiNose apparatus and the dihydroergotamine oral inhaler. I will not include transcranial magnetic stimulation, a 5-HT1F agonist, large conductance calcium-activated potassium channel openers, glial modulators or other medications and devices in early stages of development [1]. Springer-Verlag, 2011 Migraine treatment nationallicence Migraine pipeline nationallicence CGRP antagonists nationallicence Sumatriptan nationallicence Dihydroergotamine nationallicence Neurological Sciences Springer Milan 32(2011-05-01), 105-109 1590-1874 32<105 2011 32 10072 https://doi.org/10.1007/s10072-011-0542-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0542-3 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Rapoport A. David Geffen School of Medicine at UCLA, 239 South Orange Drive, 90036, Los Angeles, CA, USA aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32(2011-05-01), 105-109 1590-1874 32<105 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer