caa a22 4500 445356588 CHVBK 20180317142902.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10072-011-0532-5 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0532-5 Female reproductive steroids and neuronal excitability [Elektronische Daten] [C. Finocchi, M. Ferrari] Oestrogen and progesterone have specific receptors in the central nervous system and are able to regulate neuronal development and plasticity, neuronal excitability, mitochondrial energy production, and neurotransmitter synthesis, release, and transport. On neuronal excitability, estradiol and progesterone seem to have an opposite effect, with estradiol being excitatory and progesterone and its derivative allopregnanolone being inhibitory. Estradiol augments N-methyl-d-aspartate-mediated glutamate receptor activity, while progesterone enhances gamma-aminobutyric acid-mediated chloride conductance. Sex steroid regulation of the balance of neuroexcitatory and neuroinhibitory activities may have a role in modulating clinical susceptibility to different neurological conditions such as migraine, catamenial epilepsy, premenstrual dysphoric disorder, and premenstrual syndrome. Springer-Verlag, 2011 Reproductive steroids nationallicence Neuronal excitability nationallicence Migraine nationallicence Finocchi C. Department of Neurosciences, Ophthalmology and Genetics, University of Genova, Genoa, Italy aut Ferrari M. Department of Neurosciences, Ophthalmology and Genetics, University of Genova, Genoa, Italy aut Neurological Sciences Springer Milan 32(2011-05-01), 31-35 1590-1874 32<31 2011 32 10072 https://doi.org/10.1007/s10072-011-0532-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0532-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Finocchi C. Department of Neurosciences, Ophthalmology and Genetics, University of Genova, Genoa, Italy aut NATIONALLICENCE 700 1- Ferrari M. Department of Neurosciences, Ophthalmology and Genetics, University of Genova, Genoa, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32(2011-05-01), 31-35 1590-1874 32<31 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer