caa a22 4500 445356642 CHVBK 20180317142902.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10072-011-0551-2 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0551-2 Frovatriptan versus other triptans in the acute treatment of migraine: pooled analysis of three double-blind, randomized, cross-over, multicenter, Italian studies [Elektronische Daten] [Pietro Cortelli, Gianni Allais, Vincenzo Tullo, Chiara Benedetto, Dario Zava, Stefano Omboni, Gennaro Bussone] The objective of the study is to systematically review the efficacy and safety of frovatriptan (F) versus rizatriptan (R), zolmitriptan (Z) and almotriptan (A), through a pooled analysis of three individual studies. 414 subjects with a history of migraine with or without aura (IHS criteria) were randomized to F 2.5mg or R 10mg (study 1), F 2.5mg or Z 2.5mg (study 2), and F 2.5mg or A 12.5mg (study 3). The studies had an identical multicenter, randomized, double blind, cross-over design, with each of the two treatment periods lasting not more than 3months. The number of pain free (PF) and pain relief (PR) episodes at 2h, and the number of sustained pain free (SPF) and recurrent episodes within the 48h were the efficacy endpoints. 346 patients were included in the intention-to-treat analysis. Rate of PF episodes at 2h was 30% with F and 34% with comparators (p=NS). PR episodes at 2h were 55% for F and 59% for comparators (p=NS). SPF episodes at 48h were also similar between the two groups (22% F vs. 21% comparators). Rate of recurrence was significantly (p<0.001) lower under F (27 vs. 40% comparators). Drug-related adverse events were significantly (p<0.05) less under F, particularly cardiovascular symptoms. Our systematic analysis of individual studies suggests that F has a similar immediate efficacy, but a more sustained effect and a better tolerability than R, Z and A. Springer-Verlag, 2011 Migraine nationallicence Frovatriptan nationallicence Rizatriptan nationallicence Zolmitriptan nationallicence Almotriptan nationallicence Cortelli Pietro Clinica Neurologica, Dipartimento di Scienze Neurologiche, Università di Bologna, Via Ugo Foscolo, 7, 40123, Bologna, Italy aut Allais Gianni Department of Gynecology and Obstetrics, Women's Headache Center, University of Torino, Turin, Italy aut Tullo Vincenzo Dipartimento di Neuroscienze Cliniche, Istituto Nazionale Neurologico Carlo Besta, Milan, Italy aut Benedetto Chiara Department of Gynecology and Obstetrics, Women's Headache Center, University of Torino, Turin, Italy aut Zava Dario Istituto Lusofarmaco d'Italia, Milan, Italy aut Omboni Stefano Italian Institute of Telemedicine, Varese, Italy aut Bussone Gennaro Dipartimento di Neuroscienze Cliniche, Istituto Nazionale Neurologico Carlo Besta, Milan, Italy aut Neurological Sciences Springer Milan 32(2011-05-01), 95-98 1590-1874 32<95 2011 32 10072 https://doi.org/10.1007/s10072-011-0551-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0551-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cortelli Pietro Clinica Neurologica, Dipartimento di Scienze Neurologiche, Università di Bologna, Via Ugo Foscolo, 7, 40123, Bologna, Italy aut NATIONALLICENCE 700 1- Allais Gianni Department of Gynecology and Obstetrics, Women's Headache Center, University of Torino, Turin, Italy aut NATIONALLICENCE 700 1- Tullo Vincenzo Dipartimento di Neuroscienze Cliniche, Istituto Nazionale Neurologico Carlo Besta, Milan, Italy aut NATIONALLICENCE 700 1- Benedetto Chiara Department of Gynecology and Obstetrics, Women's Headache Center, University of Torino, Turin, Italy aut NATIONALLICENCE 700 1- Zava Dario Istituto Lusofarmaco d'Italia, Milan, Italy aut NATIONALLICENCE 700 1- Omboni Stefano Italian Institute of Telemedicine, Varese, Italy aut NATIONALLICENCE 700 1- Bussone Gennaro Dipartimento di Neuroscienze Cliniche, Istituto Nazionale Neurologico Carlo Besta, Milan, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32(2011-05-01), 95-98 1590-1874 32<95 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer