caa a22 4500 445356774 CHVBK 20180317142902.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s10072-011-0797-8 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0797-8 Loco-regional treatments in first-diagnosis glioblastoma: literature review on association between Stupp protocol and Gliadel [Elektronische Daten] [Andrea Salmaggi, Stefania Duri, Antonio Silvani, Paola Gaviani, Ida Milanesi, Cecilia Casali, Francesco Di Meco] Loco-regional chemotherapy with carmustine wafers (Gliadel) positioned at surgery and followed by radiotherapy has been shown to prolong survival in first-diagnosis glioblastoma, as well as concomitant radiochemotherapy with temozolomide. The combination of Gliadel with the Stupp protocol has mostly been investigated in retrospective studies. objective of this study was to review the literature of efficacy and toxicities in patients with first-diagnosis glioblastoma treated with surgery, Gliadel, radiotherapy and temozolomide chemotherapy. The data in the literature regarding the combined use of Gliadel with chemotherapy, concomitant with radiotherapy and adjuvant temozolomide for glioblastoma was analyzed and compared. The results on survival and toxicity are summarized. The combination of Gliadel and radiotherapy with temozolomide is well tolerated and may increase survival without a substantial increase in major toxicity. However, only prospective comparative studies will be able to address the issue of true advantage in survival with this combination. Springer-Verlag, 2011 Gliadel nationallicence Temozolomide nationallicence Glioblastoma nationallicence BCNU wafers nationallicence Salmaggi Andrea Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria, 11, 20133, Milan, Italy aut Duri Stefania Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria, 11, 20133, Milan, Italy aut Silvani Antonio Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria, 11, 20133, Milan, Italy aut Gaviani Paola Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria, 11, 20133, Milan, Italy aut Milanesi Ida Radiotherapy, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy aut Casali Cecilia Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy aut Di Meco Francesco Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy aut Neurological Sciences Springer Milan 32(2011-11-01), 241-245 1590-1874 32<241 2011 32 10072 https://doi.org/10.1007/s10072-011-0797-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0797-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Salmaggi Andrea Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria, 11, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Duri Stefania Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria, 11, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Silvani Antonio Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria, 11, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Gaviani Paola Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria, 11, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Milanesi Ida Radiotherapy, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy aut NATIONALLICENCE 700 1- Casali Cecilia Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy aut NATIONALLICENCE 700 1- Di Meco Francesco Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32(2011-11-01), 241-245 1590-1874 32<241 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer