caa a22 4500 445356820 CHVBK 20180317142902.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s10072-011-0793-z doi (NATIONALLICENCE)springer-10.1007/s10072-011-0793-z Metabolic, electrolytes disorders and tromboembolic risk in malignant glioma patients [Elektronische Daten] [A. Silvani, P. Gaviani, E. Lamperti, A. Botturi, D. Ferrari, G. Simonetti, L. Fariselli, A. Salmaggi] In malignant gliomas, the management of symptoms and minimization of side effects assume major importance. Corticosteroids provide transient relief from neurological symptoms. However, treatment with steroids is also commonly associated with considerable side-effects including: hyperglycemia, osteoporosis, myopathy, lymphopenia and others. Sometimes, antiepileptic drugs may contribute to clinical decline of neuro-oncological patients in stable disease not only by neuropsychological impairment but also by metabolic interations. Several studies have demonstrated a high frequency of hyponatremia among patients treated with carbamazepine and particularly with oxacarbamazepine. Venous thromboembolism is a common complication in patients with cancer and it is particularly high in malignant gliomas, occurring in approximately 20-30% of such patients. Prophylactic treatment in patients with glioblastoma is a key topic. The role of prophylaxis has not yet been established with certainty. Overall the data show a clear reduction of venous thromboembolic events in patients treated with intermittent pneumatic compression (IPC). The addition of enoxaparin dose of 6.000UI, starting in the perioperative period, induces an increase of major bleeding events. In the absence of availability of IPC, the use of enoxaparin 4.000UI in addition to graduated compression stockings, reduces thromboembolic events without major bleeding events. Springer-Verlag, 2011 Glioblastoma nationallicence Steroids nationallicence Side effects nationallicence Venous thromboembolism nationallicence Silvani A. Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy aut Gaviani P. Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy aut Lamperti E. Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy aut Botturi A. Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy aut Ferrari D. Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy aut Simonetti G. Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy aut Fariselli L. Department of Neurosurgery, UO Radiotherapy Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy aut Salmaggi A. Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy aut Neurological Sciences Springer Milan 32(2011-11-01), 229-231 1590-1874 32<229 2011 32 10072 https://doi.org/10.1007/s10072-011-0793-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0793-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Silvani A. Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Gaviani P. Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Lamperti E. Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Botturi A. Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Ferrari D. Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Simonetti G. Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Fariselli L. Department of Neurosurgery, UO Radiotherapy Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy aut NATIONALLICENCE 700 1- Salmaggi A. Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32(2011-11-01), 229-231 1590-1874 32<229 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer