caa a22 4500 445356839 CHVBK 20180317142903.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s10072-011-0790-2 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0790-2 Neuro-oncological diagnosis in patients without histological confirmation [Elektronische Daten] [P. Gaviani, A. Silvani, E. Lamperti, A. Botturi, G. Simonetti, D. Ferrari, A. Salmaggi] The impossibility to conduct a histological diagnosis could be due to different reasons: (1) patient's refusal to undergo surgery/biopsy. (2) Technical difficulties: despite the advance in surgical procedures, the removal of lesions that are located either in critical or in deep areas represents a considerable risk for patients. (3) Quality/quantity of the sample. In rare cases even when the surgical sample is achieved it could be impossible to reach a histological confirmation, for example due to the small amount of tissue obtained. The lack of histology leads to suboptimal therapy, incorrect prognosis, and misinterpretation of clinical trials and furthermore undermines the possibility to perform most radiation and chemotherapy protocols. In this setting the morphological data obtained with conventional MR imaging may be integrated with the metabolic, structural and perfusional information provided by new MR and metabolic techniques (spectroscopy, SPECT, PET in particular). Springer-Verlag, 2011 Histological diagnosis nationallicence Glioma nationallicence Neuro-oncology nationallicence Gaviani P. Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 11 Via Celoria, 20133, Milan, Italy aut Silvani A. Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 11 Via Celoria, 20133, Milan, Italy aut Lamperti E. Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 11 Via Celoria, 20133, Milan, Italy aut Botturi A. Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 11 Via Celoria, 20133, Milan, Italy aut Simonetti G. Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 11 Via Celoria, 20133, Milan, Italy aut Ferrari D. Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 11 Via Celoria, 20133, Milan, Italy aut Salmaggi A. Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 11 Via Celoria, 20133, Milan, Italy aut Neurological Sciences Springer Milan 32(2011-11-01), 213-215 1590-1874 32<213 2011 32 10072 https://doi.org/10.1007/s10072-011-0790-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0790-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gaviani P. Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 11 Via Celoria, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Silvani A. Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 11 Via Celoria, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Lamperti E. Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 11 Via Celoria, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Botturi A. Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 11 Via Celoria, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Simonetti G. Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 11 Via Celoria, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Ferrari D. Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 11 Via Celoria, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Salmaggi A. Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 11 Via Celoria, 20133, Milan, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32(2011-11-01), 213-215 1590-1874 32<213 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer