caa a22 4500 445356855 CHVBK 20180317142903.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s10072-011-0802-2 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0802-2 Pollo Bianca Unit of Neuropathology, Fondazione IRCCS Istituto Neurologico "C. Besta”, Via Celoria 11, 20133, Milan, Italy aut Neuropathological diagnosis of brain tumours [Elektronische Daten] [Bianca Pollo] With recent progress in radiological, pathological, immunohistochemical, molecular and genetic diagnoses, the characterisation of brain tumours has improved. The last World Health Organization (WHO) Classification of Tumours of the Central Nervous System was done in 2007, based on morphological features, growth pattern and molecular profile of neoplastic cells, defined malignancy grade. The neuropathological diagnosis and the grading of each histotype are based on identification of histopathological criteria and immunohistochemical data. Molecular and genetic profiles may identify different tumour subtypes varying in biological and clinical behaviour, indicating prognostic and predictive factors. In order to investigate new therapeutic approaches, it is important to study the molecular pathways responsible for proliferation, invasion, angiogenesis, and anaplastic transformation. Different prognostic and predictive factors for glioma patients were identified by genetic studies, such as the loss of heterozygosis on chromosome 1p and 19q for oligodendrogliomas, proangiogenic factors such as Vascular Endothelial Growth Factor for glioblastomas and the methylation status of gene promoter of MethylGuanine-MethylTransferase. In conclusion, the prognostic evaluation and the therapeutic strategies for patients depend on the synthesis of histological diagnosis, malignancy grade, gene-molecular profile, radiological images, surgical resection and clinical findings (age, tumour location, and "performance status”). Springer-Verlag, 2011 Brain tumours nationallicence Classification nationallicence Histological diagnosis nationallicence Molecular profiles nationallicence Biomarkers nationallicence Neurological Sciences Springer Milan 32(2011-11-01), 209-211 1590-1874 32<209 2011 32 10072 https://doi.org/10.1007/s10072-011-0802-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0802-2 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Pollo Bianca Unit of Neuropathology, Fondazione IRCCS Istituto Neurologico "C. Besta”, Via Celoria 11, 20133, Milan, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32(2011-11-01), 209-211 1590-1874 32<209 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer