caa a22 4500 44535688X CHVBK 20180317142903.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s10072-011-0795-x doi (NATIONALLICENCE)springer-10.1007/s10072-011-0795-x Lecture: management of chemotherapy-induced febrile neutropenia; guidelines and colony stimulating factors [Elektronische Daten] [Giuseppe Procopio, Monica Niger, Isabella Testa] Chemotherapy-induced febrile neutropenia (FN) is a major risk factor for severe infections potentially fatal, and also a dose-limiting toxicity, so causing dose reductions and/or delays in scheduled chemotherapy. This lecture provides recommendations for the use of G-CSF in adult cancer patients at risk of chemotherapy-induced FN. If expected risk of FN is equal or superior to 20%, a primary prophylaxis of FN with G-CSF is recommended. Primary prophylaxis can be considered in case of intermediate 10-20% risk of FN, in presence of factors that increase the frequency/risk of FN, such as age >65, advanced disease, prior episode of FN, poor performance status, radiotherapy to a wide body area (>20%). In case of low risk of FN (<10%), primary prophylaxis is not recommended. We also described the differences in potency and efficacy between two G-CSF, lenograstim (glycosylated) and filgrastim (non-glycosylated), which should be considered when deciding the G-CSF for each patient, particularly in high risk settings for FN. Springer-Verlag, 2011 Chemotherapy-induced febrile neutropenia nationallicence Guidelines nationallicence Colony stimulating factors nationallicence Procopio Giuseppe Fondazione IRCCS-Istituto Nazionale Tumori, Milan, Italy aut Niger Monica Fondazione IRCCS-Istituto Nazionale Tumori, Milan, Italy aut Testa Isabella Fondazione IRCCS-Istituto Nazionale Tumori, Milan, Italy aut Neurological Sciences Springer Milan 32(2011-11-01), 217-219 1590-1874 32<217 2011 32 10072 https://doi.org/10.1007/s10072-011-0795-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0795-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Procopio Giuseppe Fondazione IRCCS-Istituto Nazionale Tumori, Milan, Italy aut NATIONALLICENCE 700 1- Niger Monica Fondazione IRCCS-Istituto Nazionale Tumori, Milan, Italy aut NATIONALLICENCE 700 1- Testa Isabella Fondazione IRCCS-Istituto Nazionale Tumori, Milan, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32(2011-11-01), 217-219 1590-1874 32<217 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer