caa a22 4500 445356928 CHVBK 20180317142903.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10072-011-0561-0 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0561-0 Memantine attenuates the impairment of spatial learning and memory of pentylenetetrazol-kindled rats [Elektronische Daten] [Li-Jing Jia, Wei-Ping Wang, Zhou-Ping Li, Jun-Li Zhen, Li-Wei An, Rui-Sheng Duan] Cognitive disorders after epilepsy can have a great impact on the quality of life of epileptic patients, though it has not drawn much attention. Even after identified, it is often undertreated or has gone untreated. Memantine has been approved to treat moderate to severe Alzheimer disease (AD), which is characterized by cognitive impairment. In present study, we determined the effects of memantine on PTZ-kindled rats, which can mimic the postseizure dysfunction that resembles symptoms observed in human epilepsy. We found that memantine can ameliorate the spatial learning and memory of epileptic rats. But contrary to previous claims that memantine can improve cognition in AD patients, without serious side effects on normal learning and memory abilities, we found that rats treated only with memantine exhibited the impaired spatial learning and memory ability. We conclude that memantine can improve cognition related to an excitotoxicity-induced pathologic state, but the potential side effects of memantine on the physiological processes should be considered. Springer-Verlag, 2011 Epilepsy nationallicence Cognition nationallicence Spatial learning and memory nationallicence Kindling nationallicence Memantine nationallicence Pentylenetetrazol nationallicence Jia Li-Jing Department of Neurology, The Second Hospital of Hebei Medical University, 050000, Shijiazhuang, People's Republic of China aut Wang Wei-Ping Department of Neurology, The Second Hospital of Hebei Medical University, 050000, Shijiazhuang, People's Republic of China aut Li Zhou-Ping Department of Neurology, The Second Hospital of Hebei Medical University, 050000, Shijiazhuang, People's Republic of China aut Zhen Jun-Li Department of Neurology, The Second Hospital of Hebei Medical University, 050000, Shijiazhuang, People's Republic of China aut An Li-Wei Department of Neurology, The Second Hospital of Hebei Medical University, 050000, Shijiazhuang, People's Republic of China aut Duan Rui-Sheng Department of Neurology, The Second Hospital of Hebei Medical University, 050000, Shijiazhuang, People's Republic of China aut Neurological Sciences Springer Milan 32/4(2011-08-01), 609-613 1590-1874 32:4<609 2011 32 10072 https://doi.org/10.1007/s10072-011-0561-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0561-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jia Li-Jing Department of Neurology, The Second Hospital of Hebei Medical University, 050000, Shijiazhuang, People's Republic of China aut NATIONALLICENCE 700 1- Wang Wei-Ping Department of Neurology, The Second Hospital of Hebei Medical University, 050000, Shijiazhuang, People's Republic of China aut NATIONALLICENCE 700 1- Li Zhou-Ping Department of Neurology, The Second Hospital of Hebei Medical University, 050000, Shijiazhuang, People's Republic of China aut NATIONALLICENCE 700 1- Zhen Jun-Li Department of Neurology, The Second Hospital of Hebei Medical University, 050000, Shijiazhuang, People's Republic of China aut NATIONALLICENCE 700 1- An Li-Wei Department of Neurology, The Second Hospital of Hebei Medical University, 050000, Shijiazhuang, People's Republic of China aut NATIONALLICENCE 700 1- Duan Rui-Sheng Department of Neurology, The Second Hospital of Hebei Medical University, 050000, Shijiazhuang, People's Republic of China aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/4(2011-08-01), 609-613 1590-1874 32:4<609 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer