caa a22 4500 445356936 CHVBK 20180317142903.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10072-011-0639-8 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0639-8 Spatial patterns of TDP-43 neuronal cytoplasmic inclusions (NCI) in fifteen cases of frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP) [Elektronische Daten] [Richard Armstrong, Nigel Cairns] Neuronal cytoplasmic inclusions (NCI) immunoreactive for transactive response DNA-binding protein (TDP-43) are the pathological hallmark of frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP). We studied the spatial patterns of the TDP-43 immunoreactive NCI in the frontal and temporal cortex of 15 cases of FTLD-TDP. The NCI were distributed parallel to the tissue boundary predominantly in regular clusters 50-400μm in diameter. In five cortical areas, the size of the clusters approximated to the cells of the cortico-cortical pathways. In most regions, cluster size was smaller than 400μm. There were no significant differences in spatial patterns between familial and sporadic cases. Cluster size of the NCI was not correlated with disease duration, brain weight, Braak stage, or disease subtype. The spatial pattern of the NCI was similar to that of neuronal inclusions in other neurodegenerative diseases and may reflect a common pattern of degeneration involving the cortico-cortical projections. Springer-Verlag, 2011 Frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP) nationallicence TAR DNA-binding protein of 43kDa (TDP-43) nationallicence Neuronal cytoplasmic inclusions (NCI) nationallicence Spatial pattern nationallicence Armstrong Richard Vision Sciences, Aston University, B4 7ET, Birmingham, UK aut Cairns Nigel Departments of Neurology and Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA aut Neurological Sciences Springer Milan 32/4(2011-08-01), 653-659 1590-1874 32:4<653 2011 32 10072 https://doi.org/10.1007/s10072-011-0639-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0639-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Armstrong Richard Vision Sciences, Aston University, B4 7ET, Birmingham, UK aut NATIONALLICENCE 700 1- Cairns Nigel Departments of Neurology and Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/4(2011-08-01), 653-659 1590-1874 32:4<653 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer