caa a22 4500 445357045 CHVBK 20180317142903.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10072-011-0581-9 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0581-9 Isolated progressive cognitive impairment and depression in a patient with neuroradiological features suggestive of multiple sclerosis [Elektronische Daten] [Diana Ferraro, Anna Simone, Elisa Merelli, Jessica Mandrioli, Maria Molinari, Paolo Nichelli, Patrizia Sola] We report the case of a woman who started complaining of depression, attention and memory problems at the age of 49. Over the following 6years, serial neuropsychological assessments showed fluctuating, but overall progressively worsening, performances in tests exploring attention, working memory, language and executive functions. Cerebrospinal fluid (CSF) examination showed identical IgG oligoclonal bands in serum and CSF. Neurological examination, to date, only reveals minimal pyramidal and cerebellar signs. Although typical clinical and laboratory evidence indicating a diagnosis of multiple sclerosis (MS) in this patient is lacking, an extensive diagnostic work-up ruled out many other causes of leukoencephalopathy and neuroradiological features strongly suggest this diagnosis. Multiple sclerosis may present with cognitive or neuropsychiatric symptoms; this should be kept in mind, especially in younger patients, even in the absence of "classical” physical symptoms. Springer-Verlag, 2011 Multiple sclerosis nationallicence Cognitive impairment nationallicence Depression nationallicence Ferraro Diana Neurology Unit, Department of Neurosciences, Nuovo Ospedale Civile S. Agostino Estense, University of Modena and Reggio Emilia, Via P. Giardini, 1355, 41100, Baggiovara (MO), Italy aut Simone Anna Neurology Unit, Department of Neurosciences, Nuovo Ospedale Civile S. Agostino Estense, University of Modena and Reggio Emilia, Via P. Giardini, 1355, 41100, Baggiovara (MO), Italy aut Merelli Elisa Neurology Unit, Department of Neurosciences, Nuovo Ospedale Civile S. Agostino Estense, University of Modena and Reggio Emilia, Via P. Giardini, 1355, 41100, Baggiovara (MO), Italy aut Mandrioli Jessica Neurology Unit, Department of Neurosciences, Nuovo Ospedale Civile S. Agostino Estense, University of Modena and Reggio Emilia, Via P. Giardini, 1355, 41100, Baggiovara (MO), Italy aut Molinari Maria Neurology Unit, Department of Neurosciences, Nuovo Ospedale Civile S. Agostino Estense, University of Modena and Reggio Emilia, Via P. Giardini, 1355, 41100, Baggiovara (MO), Italy aut Nichelli Paolo Neurology Unit, Department of Neurosciences, Nuovo Ospedale Civile S. Agostino Estense, University of Modena and Reggio Emilia, Via P. Giardini, 1355, 41100, Baggiovara (MO), Italy aut Sola Patrizia Neurology Unit, Department of Neurosciences, Nuovo Ospedale Civile S. Agostino Estense, University of Modena and Reggio Emilia, Via P. Giardini, 1355, 41100, Baggiovara (MO), Italy aut Neurological Sciences Springer Milan 32/4(2011-08-01), 695-697 1590-1874 32:4<695 2011 32 10072 https://doi.org/10.1007/s10072-011-0581-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0581-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ferraro Diana Neurology Unit, Department of Neurosciences, Nuovo Ospedale Civile S. Agostino Estense, University of Modena and Reggio Emilia, Via P. Giardini, 1355, 41100, Baggiovara (MO), Italy aut NATIONALLICENCE 700 1- Simone Anna Neurology Unit, Department of Neurosciences, Nuovo Ospedale Civile S. Agostino Estense, University of Modena and Reggio Emilia, Via P. Giardini, 1355, 41100, Baggiovara (MO), Italy aut NATIONALLICENCE 700 1- Merelli Elisa Neurology Unit, Department of Neurosciences, Nuovo Ospedale Civile S. Agostino Estense, University of Modena and Reggio Emilia, Via P. Giardini, 1355, 41100, Baggiovara (MO), Italy aut NATIONALLICENCE 700 1- Mandrioli Jessica Neurology Unit, Department of Neurosciences, Nuovo Ospedale Civile S. Agostino Estense, University of Modena and Reggio Emilia, Via P. Giardini, 1355, 41100, Baggiovara (MO), Italy aut NATIONALLICENCE 700 1- Molinari Maria Neurology Unit, Department of Neurosciences, Nuovo Ospedale Civile S. Agostino Estense, University of Modena and Reggio Emilia, Via P. Giardini, 1355, 41100, Baggiovara (MO), Italy aut NATIONALLICENCE 700 1- Nichelli Paolo Neurology Unit, Department of Neurosciences, Nuovo Ospedale Civile S. Agostino Estense, University of Modena and Reggio Emilia, Via P. Giardini, 1355, 41100, Baggiovara (MO), Italy aut NATIONALLICENCE 700 1- Sola Patrizia Neurology Unit, Department of Neurosciences, Nuovo Ospedale Civile S. Agostino Estense, University of Modena and Reggio Emilia, Via P. Giardini, 1355, 41100, Baggiovara (MO), Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/4(2011-08-01), 695-697 1590-1874 32:4<695 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer