caa a22 4500 44535707X CHVBK 20180317142903.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10072-011-0653-x doi (NATIONALLICENCE)springer-10.1007/s10072-011-0653-x Microscopic polyangiitis presenting with peripheral and central neurological manifestations [Elektronische Daten] [S. Sassi, I. Ghorbel, H. Mizouni, M. Houman, F. Hentati] Although peripheral neuropathy is a common complication of microscopic angiitis, manifestations involving the muscle and the central nervous system have been rarely reported. We describe a 48-year-old man who rapidly developed a clinical picture of mononeuritis multiplex. A month after the appearance of the primary symptoms, he became comatose and had left hemiplegia in relation with a massive cerebral haematoma. Laboratory data revealed signs of inflammation, glomerular dysfunction with microhaematuria, and positive myeloperoxidase-antineutrophil cytoplasmic antibodies. The neuromuscular biopsy disclosed a small-vessel vasculitis, consisting with microscopic angiitis, associated with myositis and extensive axonal loss. The patient had surgical evacuation of the haematoma and received immunosuppressive therapy with good outcome. Thus, microscopic angiitis should be considered as a differential diagnosis in cases of myositis and intracerebral haemorrhage. Springer-Verlag, 2011 Microscopic polyangiitis nationallicence Vasculitis nationallicence Haemorrhagic stroke nationallicence Mononeuritis multiplex nationallicence Myositis nationallicence Sassi S. Neurology Department, National Institute of Neurology, Tunis, Tunisia aut Ghorbel I. Neurology Department, National Institute of Neurology, Tunis, Tunisia aut Mizouni H. Neurology Department, National Institute of Neurology, Tunis, Tunisia aut Houman M. Neurology Department, National Institute of Neurology, Tunis, Tunisia aut Hentati F. Neurology Department, National Institute of Neurology, Tunis, Tunisia aut Neurological Sciences Springer Milan 32/4(2011-08-01), 727-729 1590-1874 32:4<727 2011 32 10072 https://doi.org/10.1007/s10072-011-0653-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0653-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sassi S. Neurology Department, National Institute of Neurology, Tunis, Tunisia aut NATIONALLICENCE 700 1- Ghorbel I. Neurology Department, National Institute of Neurology, Tunis, Tunisia aut NATIONALLICENCE 700 1- Mizouni H. Neurology Department, National Institute of Neurology, Tunis, Tunisia aut NATIONALLICENCE 700 1- Houman M. Neurology Department, National Institute of Neurology, Tunis, Tunisia aut NATIONALLICENCE 700 1- Hentati F. Neurology Department, National Institute of Neurology, Tunis, Tunisia aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/4(2011-08-01), 727-729 1590-1874 32:4<727 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer