caa a22 4500 445357177 CHVBK 20180317142904.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10072-011-0494-7 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0494-7 Progressive multifocal leukoencephalopathy following chemotherapy for lung cancer [Elektronische Daten] [Antonio Palmieri, L. Valentinis, S. Bazzano, A. Baldi, F. Orlando, S. Tenaglia, S. D'Anna] Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by the JC virus infection and with a frequent lethal outcome. PML usually occurs in immunocompromised subjects, such as HIV-positive individuals, as well as in other conditions characterized by depletion of cellular immunity, including hematological malignancies, autoimmune diseases, and immunomodulatory therapies. We describe the case of a 76-year-old man affected by advanced non-small cell lung cancer who developed PML after six cycles of carboplatin/gemcitabine therapy, during which a transitory leucopenia developed. The patient deceased a few months after the onset of the symptoms. Chemotherapy appears to be uncommon, but definite condition associated to PML. Springer-Verlag, 2011 Progressive multifocal leukoencephalopathy nationallicence Chemotherapy nationallicence Lung cancer nationallicence Palmieri Antonio Department of Neurology, Hospital of Portogruaro, via Zappetti 58, 30026, Portogruaro, VE, Italy aut Valentinis L. Department of Neurology, Hospital of Portogruaro, via Zappetti 58, 30026, Portogruaro, VE, Italy aut Bazzano S. Department of Neurology, Hospital of Portogruaro, via Zappetti 58, 30026, Portogruaro, VE, Italy aut Baldi A. Department of Neurology, Hospital of Portogruaro, via Zappetti 58, 30026, Portogruaro, VE, Italy aut Orlando F. Department of Neurology, Hospital of Portogruaro, via Zappetti 58, 30026, Portogruaro, VE, Italy aut Tenaglia S. Department of Neurology, Hospital of Portogruaro, via Zappetti 58, 30026, Portogruaro, VE, Italy aut D'Anna S. Department of Neurology, Hospital of Portogruaro, via Zappetti 58, 30026, Portogruaro, VE, Italy aut Neurological Sciences Springer Milan 32/4(2011-08-01), 683-685 1590-1874 32:4<683 2011 32 10072 https://doi.org/10.1007/s10072-011-0494-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0494-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Palmieri Antonio Department of Neurology, Hospital of Portogruaro, via Zappetti 58, 30026, Portogruaro, VE, Italy aut NATIONALLICENCE 700 1- Valentinis L. Department of Neurology, Hospital of Portogruaro, via Zappetti 58, 30026, Portogruaro, VE, Italy aut NATIONALLICENCE 700 1- Bazzano S. Department of Neurology, Hospital of Portogruaro, via Zappetti 58, 30026, Portogruaro, VE, Italy aut NATIONALLICENCE 700 1- Baldi A. Department of Neurology, Hospital of Portogruaro, via Zappetti 58, 30026, Portogruaro, VE, Italy aut NATIONALLICENCE 700 1- Orlando F. Department of Neurology, Hospital of Portogruaro, via Zappetti 58, 30026, Portogruaro, VE, Italy aut NATIONALLICENCE 700 1- Tenaglia S. Department of Neurology, Hospital of Portogruaro, via Zappetti 58, 30026, Portogruaro, VE, Italy aut NATIONALLICENCE 700 1- D'Anna S. Department of Neurology, Hospital of Portogruaro, via Zappetti 58, 30026, Portogruaro, VE, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/4(2011-08-01), 683-685 1590-1874 32:4<683 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer