caa a22 4500 445357223 CHVBK 20180317142904.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10072-011-0589-1 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0589-1 The "eye of the tiger” sign in pure akinesia with gait freezing [Elektronische Daten] [Roberto Erro, Marianna Amboni, Carmine Vitale, Katia Longo, Mariangela Rocco, Carmela Russo, Sabina Pappatà, Arturo Brunetti, Paolo Barone] The "eye of the tiger” is a neuroradiologic sign due to iron deposition in the globus pallidus: it appears as diffuse low signal intensity with a central area of high signal intensity confined to the globus pallidus. The "eye of the tiger” sign has been associated with neurodegeneration with brain iron accumulation type 1 (NBIA1), a condition caused by mutations in the gene encoding pantothenate kinase 2 (PANK2). However, the specificity of this neuroradiologic sign has been already challenged and it has been described in other neurodegenerative diseases. Here, we report the first case of a patient suffering from pure akinesia with gait freezing with the "eye of the tiger” sign in T2-weighted MRI sequences. All clinical, laboratory and radiologic data excluded other diagnosis and genetic testing excluded PANK2 mutations suggesting that the "eye of the tiger” is not specific for NBIA1 and may also occur in other movement disorders. Springer-Verlag, 2011 The "eye of the tiger” sign nationallicence Pure akinesia nationallicence Freezing of gait nationallicence FOG nationallicence Movement disorders nationallicence NBIA nationallicence Erro Roberto Department of Neurological Sciences, University of Naples "Federico II”, Via S. Pansini 5, 80131, Naples, Italy aut Amboni Marianna Department of Neurological Sciences, University of Naples "Federico II”, Via S. Pansini 5, 80131, Naples, Italy aut Vitale Carmine Department of Neurological Sciences, University of Naples "Federico II”, Via S. Pansini 5, 80131, Naples, Italy aut Longo Katia Department of Neurological Sciences, University of Naples "Federico II”, Via S. Pansini 5, 80131, Naples, Italy aut Rocco Mariangela Department of Neurological Sciences, University of Naples "Federico II”, Via S. Pansini 5, 80131, Naples, Italy aut Russo Carmela Department of Diagnostic Imaging, Neuroradiology, University of Naples "Federico II” and IBB-CNR, Naples, Italy aut Pappatà Sabina Department of Diagnostic Imaging, Neuroradiology, University of Naples "Federico II” and IBB-CNR, Naples, Italy aut Brunetti Arturo Department of Diagnostic Imaging, Neuroradiology, University of Naples "Federico II” and IBB-CNR, Naples, Italy aut Barone Paolo Department of Neurological Sciences, University of Naples "Federico II”, Via S. Pansini 5, 80131, Naples, Italy aut Neurological Sciences Springer Milan 32/4(2011-08-01), 703-705 1590-1874 32:4<703 2011 32 10072 https://doi.org/10.1007/s10072-011-0589-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0589-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Erro Roberto Department of Neurological Sciences, University of Naples "Federico II”, Via S. Pansini 5, 80131, Naples, Italy aut NATIONALLICENCE 700 1- Amboni Marianna Department of Neurological Sciences, University of Naples "Federico II”, Via S. Pansini 5, 80131, Naples, Italy aut NATIONALLICENCE 700 1- Vitale Carmine Department of Neurological Sciences, University of Naples "Federico II”, Via S. Pansini 5, 80131, Naples, Italy aut NATIONALLICENCE 700 1- Longo Katia Department of Neurological Sciences, University of Naples "Federico II”, Via S. Pansini 5, 80131, Naples, Italy aut NATIONALLICENCE 700 1- Rocco Mariangela Department of Neurological Sciences, University of Naples "Federico II”, Via S. Pansini 5, 80131, Naples, Italy aut NATIONALLICENCE 700 1- Russo Carmela Department of Diagnostic Imaging, Neuroradiology, University of Naples "Federico II” and IBB-CNR, Naples, Italy aut NATIONALLICENCE 700 1- Pappatà Sabina Department of Diagnostic Imaging, Neuroradiology, University of Naples "Federico II” and IBB-CNR, Naples, Italy aut NATIONALLICENCE 700 1- Brunetti Arturo Department of Diagnostic Imaging, Neuroradiology, University of Naples "Federico II” and IBB-CNR, Naples, Italy aut NATIONALLICENCE 700 1- Barone Paolo Department of Neurological Sciences, University of Naples "Federico II”, Via S. Pansini 5, 80131, Naples, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/4(2011-08-01), 703-705 1590-1874 32:4<703 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer