caa a22 4500 445357282 CHVBK 20180317142904.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10072-011-0486-7 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0486-7 Effects of heating coagulation of middle meningeal artery on plasma CGRP level and c-fos expression in migraine rat triggered by nitroglycerin [Elektronische Daten] [Xiaofeng Zhu, Yuechen Han, Wenping Xiong, Wenwen Liu, Sumei Lu, Jianfeng Li, Haibo Wang, Zhaomin Fan] Current theory or hypothesis relevant to migraine indicates that trigeminovascular system plays a pivotal role in the pathophysiology of migraine. Particularly, release of neuropeptide and induction of c-fos like immunoreactivity (c-fos LI) within trigeminal nucleus caudalis neurons are regarded as activation markers of trigeminovascular system. In the present study, we set up a rat model for migraine triggered by nitroglycerin (NTG) and coagulated the middle meningeal artery by heating. Using this model, we determined the plasma calcitonin gene-related peptide (CGRP) level as well as the expression of c-fos in trigeminal nucleus caudalis of rats. We found that NTG led to markedly increase in plasma CGRP level and c-fos expression in trigeminal nucleus caudalis compared with the isotonic saline-treated group (P<0.05). More importantly, heat coagulation of middle meningeal artery could decrease plasma CGRP level and c-fos expression in trigeminal nucleus caudalis (P<0.05). Heat coagulation of middle meningeal artery may ameliorate sufferings of rat induced by NTG and play an important role in restraining the release of CGRP as well as the activation of neurons in trigeminal nucleus caudalis in rats following NTG infusion. Springer-Verlag, 2011 Migraine nationallicence Middle meningeal artery nationallicence Trigeminal nucleus caudalis nationallicence Calcitonin gene-related peptide nationallicence C-fos nationallicence Zhu Xiaofeng Otolaryngology-Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China aut Han Yuechen Otolaryngology-Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China aut Xiong Wenping Otolaryngology-Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China aut Liu Wenwen Institute of Eye and ENT, Shandong Clinic Research Institute, Jinan, People's Republic of China aut Lu Sumei Institute of Eye and ENT, Shandong Clinic Research Institute, Jinan, People's Republic of China aut Li Jianfeng Institute of Eye and ENT, Shandong Clinic Research Institute, Jinan, People's Republic of China aut Wang Haibo Otolaryngology-Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China aut Fan Zhaomin Otolaryngology-Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China aut Neurological Sciences Springer Milan 32/4(2011-08-01), 589-594 1590-1874 32:4<589 2011 32 10072 https://doi.org/10.1007/s10072-011-0486-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0486-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhu Xiaofeng Otolaryngology-Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China aut NATIONALLICENCE 700 1- Han Yuechen Otolaryngology-Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China aut NATIONALLICENCE 700 1- Xiong Wenping Otolaryngology-Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China aut NATIONALLICENCE 700 1- Liu Wenwen Institute of Eye and ENT, Shandong Clinic Research Institute, Jinan, People's Republic of China aut NATIONALLICENCE 700 1- Lu Sumei Institute of Eye and ENT, Shandong Clinic Research Institute, Jinan, People's Republic of China aut NATIONALLICENCE 700 1- Li Jianfeng Institute of Eye and ENT, Shandong Clinic Research Institute, Jinan, People's Republic of China aut NATIONALLICENCE 700 1- Wang Haibo Otolaryngology-Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China aut NATIONALLICENCE 700 1- Fan Zhaomin Otolaryngology-Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/4(2011-08-01), 589-594 1590-1874 32:4<589 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer