caa a22 4500 445357304 CHVBK 20180317142904.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10072-011-0597-1 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0597-1 Expression of locus coeruleus mineralocorticoid receptor and glucocorticoid receptor in rats under single-prolonged stress [Elektronische Daten] [Man Li, Fang Han, Yuxiu Shi] The pathogenesis of the post-traumatic stress disorder (PTSD) may involve dysfunction of several brain structures, such as the amygdala, locus coeruleus, hippocampus, noradrenergic system as well as the hypothalamic-pituitary-adrenal (HPA) axis. The cortisol and locus coeruleus dysfunction may affect the secretion of corticosterone. The present study was designed to examine the expression of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) in the locus coeruleus in the rats treated with single-prolonged stress (SPS). The results showed that the expression of MR had a sharp decline on day 1, but gradually increased on days 4, 7, 14, and 28. The expression of GR gradually increased on days 1, 4, and 7, but decreased on days 14 and 28, respectively.MR and GR in the locus coeruleus may have a role in the development of long-term persistent neuropsychological sequelae in PTSD. Springer-Verlag, 2011 Posttraumatic stress disorders nationallicence Locus coeruleus nationallicence Mineralocorticoid receptors nationallicence Glucocorticoid receptors nationallicence Li Man Department of Histology and Embryology, Basic Medical Sciences, China Medical University, 110001, Shenyang, China aut Han Fang Department of Histology and Embryology, Basic Medical Sciences, China Medical University, 110001, Shenyang, China aut Shi Yuxiu Department of Histology and Embryology, Basic Medical Sciences, China Medical University, 110001, Shenyang, China aut Neurological Sciences Springer Milan 32/4(2011-08-01), 625-631 1590-1874 32:4<625 2011 32 10072 https://doi.org/10.1007/s10072-011-0597-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0597-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Li Man Department of Histology and Embryology, Basic Medical Sciences, China Medical University, 110001, Shenyang, China aut NATIONALLICENCE 700 1- Han Fang Department of Histology and Embryology, Basic Medical Sciences, China Medical University, 110001, Shenyang, China aut NATIONALLICENCE 700 1- Shi Yuxiu Department of Histology and Embryology, Basic Medical Sciences, China Medical University, 110001, Shenyang, China aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/4(2011-08-01), 625-631 1590-1874 32:4<625 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer