caa a22 4500 445357312 CHVBK 20180317142904.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10072-011-0633-1 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0633-1 The concept of FDG-PET endophenotype in Alzheimer's disease [Elektronische Daten] [Emmanuel During, R. Osorio, F. Elahi, L. Mosconi, M. de Leon] Often viewed as a potential tool for preclinical diagnosis in early asymptomatic stages of Alzheimer's disease (AD), the term "endophenotype” has acquired a recent popularity in the field. In this review, we analyze the construct of endophenotype—originally designed to discover genes, and examine the literature on potential endophenotypes for the late-onset form of AD (LOAD). We focus on the [18F]-fluoro-2-deoxyglucose (FDG) PET technique, which shows a characteristic pattern of hypometabolism in AD-related regions in asymptomatic carriers of the ApoE E4 allele and in children of AD mothers. We discuss the pathophysiological significance and the positive predictive accuracy of an FDG-endophenotype for LOAD in asymptomatic subjects, and discuss several applications of this endophenotype in the identification of both promoting and protective factors. Finally, we suggest that the term "endophenotype” should be reserved to the study of risk factors, and not to the preclinical diagnosis of LOAD. Springer-Verlag, 2011 Alzheimer's disease nationallicence FDG-PET nationallicence Endophenotype nationallicence Preclinical nationallicence Diagnosis nationallicence Genetics nationallicence During Emmanuel Center for Brain Health, Silberstein Alzheimer's Institute, Center of Excellence on Brain Aging at NYU Langone Medical Center, NYU School of Medicine, 145 East 32nd Street, 10016, New York, NY, USA aut Osorio R. Center for Brain Health, Silberstein Alzheimer's Institute, Center of Excellence on Brain Aging at NYU Langone Medical Center, NYU School of Medicine, 145 East 32nd Street, 10016, New York, NY, USA aut Elahi F. Department of Neurology, University of California, Los Angeles (UCLA), Los Angeles, CA, USA aut Mosconi L. Center for Brain Health, Silberstein Alzheimer's Institute, Center of Excellence on Brain Aging at NYU Langone Medical Center, NYU School of Medicine, 145 East 32nd Street, 10016, New York, NY, USA aut de Leon M. Center for Brain Health, Silberstein Alzheimer's Institute, Center of Excellence on Brain Aging at NYU Langone Medical Center, NYU School of Medicine, 145 East 32nd Street, 10016, New York, NY, USA aut Neurological Sciences Springer Milan 32/4(2011-08-01), 559-569 1590-1874 32:4<559 2011 32 10072 https://doi.org/10.1007/s10072-011-0633-1 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0633-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- During Emmanuel Center for Brain Health, Silberstein Alzheimer's Institute, Center of Excellence on Brain Aging at NYU Langone Medical Center, NYU School of Medicine, 145 East 32nd Street, 10016, New York, NY, USA aut NATIONALLICENCE 700 1- Osorio R. Center for Brain Health, Silberstein Alzheimer's Institute, Center of Excellence on Brain Aging at NYU Langone Medical Center, NYU School of Medicine, 145 East 32nd Street, 10016, New York, NY, USA aut NATIONALLICENCE 700 1- Elahi F. Department of Neurology, University of California, Los Angeles (UCLA), Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Mosconi L. Center for Brain Health, Silberstein Alzheimer's Institute, Center of Excellence on Brain Aging at NYU Langone Medical Center, NYU School of Medicine, 145 East 32nd Street, 10016, New York, NY, USA aut NATIONALLICENCE 700 1- de Leon M. Center for Brain Health, Silberstein Alzheimer's Institute, Center of Excellence on Brain Aging at NYU Langone Medical Center, NYU School of Medicine, 145 East 32nd Street, 10016, New York, NY, USA aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/4(2011-08-01), 559-569 1590-1874 32:4<559 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer