caa a22 4500 445357363 CHVBK 20180317142904.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10072-011-0624-2 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0624-2 Depression, disability and cognitive impairment in multiple sclerosis: a cross sectional Italian study [Elektronische Daten] [Flavia Mattioli, Fabio Bellomi, Chiara Stampatori, Giovanni Parrinello, Ruggero Capra] The disability, cognitive impairment, fatigue and depression are interacting features in multiple sclerosis (MS), whose relation is still unclear. The objective of this study was to evaluate in a sample of MS patients, the frequency of depressive symptoms, its predicting factors and relation with cognitive impairment, fatigue and disability. 255 consecutive MS patients and 166 healthy subjects were assessed for the presence of depressive symptoms with the Beck Depression Inventory-Fast Screen (BDI-FS). Patients with BDI-FS ≥4 were further investigated for the presence of neuropsychological impairment. Depressive symptoms were significantly more frequent and severe in patients than in controls. EDSS score was the only predicting factor of depression (3.5=threshold EDSS score for depressive symptoms) in patients, whereas neuropsychological impairment was not correlated with BDI-FS and fatigue was found to be significantly correlated with attention, executive function and memory test scores, as well as with BDI-FS score in patients. Springer-Verlag, 2011 Multiple sclerosis nationallicence Depression nationallicence Memory nationallicence Disability nationallicence Mattioli Flavia Neuropsychology Unit, Spedali Civili of Brescia, Via Nikolajewka 13, 25123, Brescia, Italy aut Bellomi Fabio Neuropsychology Unit, Spedali Civili of Brescia, Via Nikolajewka 13, 25123, Brescia, Italy aut Stampatori Chiara Neuropsychology Unit, Spedali Civili of Brescia, Via Nikolajewka 13, 25123, Brescia, Italy aut Parrinello Giovanni Facoltà di Medicina e Chirurgia, Università degli Studi di Brescia, Via Valsabbina, 1, 25123, Brescia, Italy aut Capra Ruggero Centro Sclerosi Multipla, Spedali Civili of Brescia, Ospedale di Montichiari, Brescia, Italy aut Neurological Sciences Springer Milan 32/5(2011-10-01), 825-832 1590-1874 32:5<825 2011 32 10072 https://doi.org/10.1007/s10072-011-0624-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0624-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mattioli Flavia Neuropsychology Unit, Spedali Civili of Brescia, Via Nikolajewka 13, 25123, Brescia, Italy aut NATIONALLICENCE 700 1- Bellomi Fabio Neuropsychology Unit, Spedali Civili of Brescia, Via Nikolajewka 13, 25123, Brescia, Italy aut NATIONALLICENCE 700 1- Stampatori Chiara Neuropsychology Unit, Spedali Civili of Brescia, Via Nikolajewka 13, 25123, Brescia, Italy aut NATIONALLICENCE 700 1- Parrinello Giovanni Facoltà di Medicina e Chirurgia, Università degli Studi di Brescia, Via Valsabbina, 1, 25123, Brescia, Italy aut NATIONALLICENCE 700 1- Capra Ruggero Centro Sclerosi Multipla, Spedali Civili of Brescia, Ospedale di Montichiari, Brescia, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/5(2011-10-01), 825-832 1590-1874 32:5<825 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer