caa a22 4500 445357401 CHVBK 20180317142904.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10072-011-0723-0 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0723-0 Fulminant multiple sclerosis (MS) [Elektronische Daten] [Mohammad Rohani, Shadi Ghourchian] Fulminant multiple sclerosis (MS) is the most malignant form of MS which usually leads to death in few weeks. Although it can be accompanied by optic neuritis (ON), but long interval between ON and the grave onset has not been reported. Fulminant MS usually occurs as the first onset and previous ON is not common. We report a rare case of 30-year-old woman with a history of ON 1year ago. The rapid deterioration to vegetative state followed by a seizure and previous ON differentiated this case from previous reported cases. The differential diagnosis of a rapidly progressive leucoencephalopathy in this patient includes inflammatory, vascular, infectious and toxic disorders. Regarding the previous history of optic neuritis with positive brain MRI (multiple T2 hyperintense lesions in white matter) in our patient, multiple sclerosis is the most probable diagnosis. More effective treatments, such as plasmapheresis and cyclophosphamide, that influenced on the prognosis of some previous patients could be useful, but should be performed before progressive brain atrophy emerges. Springer-Verlag, 2011 Fulminant multiple sclerosis (MS) nationallicence Optic neuritis (ON) nationallicence Vegetative state nationallicence Progressive brain atrophy nationallicence Rohani Mohammad Rasoul-e-Akram Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran aut Ghourchian Shadi Medical Students' Research Committee of Tehran University of Medical Sciences (SSRC), Hemmat expressway, Tehran, Iran aut Neurological Sciences Springer Milan 32/5(2011-10-01), 953-957 1590-1874 32:5<953 2011 32 10072 https://doi.org/10.1007/s10072-011-0723-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0723-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rohani Mohammad Rasoul-e-Akram Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran aut NATIONALLICENCE 700 1- Ghourchian Shadi Medical Students' Research Committee of Tehran University of Medical Sciences (SSRC), Hemmat expressway, Tehran, Iran aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/5(2011-10-01), 953-957 1590-1874 32:5<953 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer