caa a22 4500 445357444 CHVBK 20180317142904.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10072-010-0468-1 doi (NATIONALLICENCE)springer-10.1007/s10072-010-0468-1 Medulloblastoma and gliomatosis cerebri: rare brain tumors in multiple sclerosis patients [Elektronische Daten] [Ana da Silva, Sara dos Santos Cavaco, Ricardo Taipa, Pedro Pinto, Manuel Pires] The simultaneous appearance of both multiple sclerosis (MS) and central nervous system (CNS) tumors is relatively uncommon. Whether the co-existence of two diseases is due to chance alone or the result of a causal relationship is still a matter of debate. There is also controversy about the effect of long-term exposure of MS patients to immunomodulatory drugs on the incidence of cancer. This paper reports two cases of rare CNS tumors (i.e., medulloblastoma and gliomatosis cerebri) in adult MS patients. Our cases emphasize that when uncommon neurological features appear in patients with MS, brain magnetic resonance imaging (MRI) ought to be done and brain biopsy should be considered to exclude a concomitant CNS disorder. These procedures are essential for the differential diagnosis and early treatment. Springer-Verlag, 2010 MRI nationallicence Multiple sclerosis nationallicence Neuroimmunology nationallicence Neurooncology nationallicence Neuropathology nationallicence da Silva Ana Serviço de Neurologia, Largo do Prof Abel Salazar, Centro Hospitalar do Porto/Hospital de Santo António, 4099-001, Porto, Portugal aut dos Santos Cavaco Sara Departamento de Doenças do Sistema Nervoso e Orgãos dos Sentidos, Unidade de Neuropsicologia, Centro Hospitalar do Porto/Hospital de Santo António, 4099-001, Porto, Portugal aut Taipa Ricardo Serviço de Neurologia, Largo do Prof Abel Salazar, Centro Hospitalar do Porto/Hospital de Santo António, 4099-001, Porto, Portugal aut Pinto Pedro Servico de Neurorradiologia, Centro Hospitalar do Porto/Hospital de Santo António, 4099-001, Porto, Portugal aut Pires Manuel Unidade de Neuropatologia, Centro Hospitalar do Porto/Hospital de Santo António, 4099-001, Porto, Portugal aut Neurological Sciences Springer Milan 32/5(2011-10-01), 893-897 1590-1874 32:5<893 2011 32 10072 https://doi.org/10.1007/s10072-010-0468-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-010-0468-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- da Silva Ana Serviço de Neurologia, Largo do Prof Abel Salazar, Centro Hospitalar do Porto/Hospital de Santo António, 4099-001, Porto, Portugal aut NATIONALLICENCE 700 1- dos Santos Cavaco Sara Departamento de Doenças do Sistema Nervoso e Orgãos dos Sentidos, Unidade de Neuropsicologia, Centro Hospitalar do Porto/Hospital de Santo António, 4099-001, Porto, Portugal aut NATIONALLICENCE 700 1- Taipa Ricardo Serviço de Neurologia, Largo do Prof Abel Salazar, Centro Hospitalar do Porto/Hospital de Santo António, 4099-001, Porto, Portugal aut NATIONALLICENCE 700 1- Pinto Pedro Servico de Neurorradiologia, Centro Hospitalar do Porto/Hospital de Santo António, 4099-001, Porto, Portugal aut NATIONALLICENCE 700 1- Pires Manuel Unidade de Neuropatologia, Centro Hospitalar do Porto/Hospital de Santo António, 4099-001, Porto, Portugal aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/5(2011-10-01), 893-897 1590-1874 32:5<893 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer