caa a22 4500 445357452 CHVBK 20180317142904.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10072-011-0499-2 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0499-2 Multiple sclerosis in Italy: cost-of-illness study [Elektronische Daten] [F. Patti, M. Amato, M. Trojano, C. Solaro, A. Pappalardo, V. Zipoli, E. Portaccio, D. Paolicelli, A. Paolillo, F. Mennini, A. Marcellusi, C. Ricci, M. Battaglia] This study estimates the direct costs of multiple sclerosis (MS) in Italy from the perspective of the National Health System. Patients diagnosed with MS for ≥1year prior to study entry were included in the analysis; neurological disability was assessed using the Expanded Disability Status Scale (EDSS). Cost variables were analyzed according to: MS phenotype, disease course over the previous year and EDSS rating. A total of 510 patients were included in the analysis. Overall costs were significantly higher for relapsing-remitting MS and secondary progressive MS than for primary progressive MS (P<0.05). Costs were higher for EDSS scores 0.0-3.5 and 4.0-6.0 than for scores>6.0 (P<0.05). The extrapolated data gave an estimated annual direct cost of MS per patient of €18,030. In conclusion, relapsing-remitting MS or secondary progressive MS phenotypes and lower estimated EDSS scores appear to be associated with higher costs. Springer-Verlag, 2011 Cost of illness nationallicence Immunomodulators nationallicence Multiple sclerosis nationallicence Relapsing-remitting multiple sclerosis nationallicence Secondary progressive multiple sclerosis nationallicence Patti F. Multiple Sclerosis Centre Sicilia Region, First Neurology Clinic, University Hospital Catania, Catania, Italy aut Amato M. Department of Neurology, University of Florence, Florence, Italy aut Trojano M. Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy aut Solaro C. Department of Neurology ASL3 Genovese, Genoa, Italy aut Pappalardo A. Multiple Sclerosis Centre Sicilia Region, First Neurology Clinic, University Hospital Catania, Catania, Italy aut Zipoli V. Department of Neurology, University of Florence, Florence, Italy aut Portaccio E. Department of Neurology, University of Florence, Florence, Italy aut Paolicelli D. Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy aut Paolillo A. Merck Serono Italy—An Affiliate of Merck KGA, Darmsdadt, Germany aut Mennini F. CEIS Sanità (CHEM—Centre for Health Economics and Management), Faculty of Economics, University of Tor Vergata, Via Columbia, 2, 00133, Rome, Italy aut Marcellusi A. CEIS Sanità (CHEM—Centre for Health Economics and Management), Faculty of Economics, University of Tor Vergata, Via Columbia, 2, 00133, Rome, Italy aut Ricci C. Department of Physiopathology and Experimental Medicine and Public Health, University of Siena, Siena, Italy aut Battaglia M. Department of Physiopathology and Experimental Medicine and Public Health, University of Siena, Siena, Italy aut Neurological Sciences Springer Milan 32/5(2011-10-01), 787-794 1590-1874 32:5<787 2011 32 10072 https://doi.org/10.1007/s10072-011-0499-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0499-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Patti F. Multiple Sclerosis Centre Sicilia Region, First Neurology Clinic, University Hospital Catania, Catania, Italy aut NATIONALLICENCE 700 1- Amato M. Department of Neurology, University of Florence, Florence, Italy aut NATIONALLICENCE 700 1- Trojano M. Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy aut NATIONALLICENCE 700 1- Solaro C. Department of Neurology ASL3 Genovese, Genoa, Italy aut NATIONALLICENCE 700 1- Pappalardo A. Multiple Sclerosis Centre Sicilia Region, First Neurology Clinic, University Hospital Catania, Catania, Italy aut NATIONALLICENCE 700 1- Zipoli V. Department of Neurology, University of Florence, Florence, Italy aut NATIONALLICENCE 700 1- Portaccio E. Department of Neurology, University of Florence, Florence, Italy aut NATIONALLICENCE 700 1- Paolicelli D. Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy aut NATIONALLICENCE 700 1- Paolillo A. Merck Serono Italy—An Affiliate of Merck KGA, Darmsdadt, Germany aut NATIONALLICENCE 700 1- Mennini F. CEIS Sanità (CHEM—Centre for Health Economics and Management), Faculty of Economics, University of Tor Vergata, Via Columbia, 2, 00133, Rome, Italy aut NATIONALLICENCE 700 1- Marcellusi A. CEIS Sanità (CHEM—Centre for Health Economics and Management), Faculty of Economics, University of Tor Vergata, Via Columbia, 2, 00133, Rome, Italy aut NATIONALLICENCE 700 1- Ricci C. Department of Physiopathology and Experimental Medicine and Public Health, University of Siena, Siena, Italy aut NATIONALLICENCE 700 1- Battaglia M. Department of Physiopathology and Experimental Medicine and Public Health, University of Siena, Siena, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/5(2011-10-01), 787-794 1590-1874 32:5<787 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer