caa a22 4500 445357487 CHVBK 20180317142905.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10072-011-0480-0 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0480-0 Obsessive-compulsive disorder: a new risk factor for Alzheimer disease? [Elektronische Daten] [Hela Mrabet Khiari, Afef Achouri, Nadia Ben Ali, Aroua Cherif, Hend Batti, Taieb Messaoud, Amel Mrabet] We describe a case of a 75-year-old woman referred to the Memory Clinic of the neurological Department of Charles Nicolle Hospital, Tunis, for cognitive decline and behavioral disturbances. Her past medical history was marked by severe obsessive-compulsive disorder (OCD) with contamination obsessions and washing compulsions. She has a family history for OCD and/or of dementia in 15 members. Clinical features, along with neuropsychological findings and Brain imaging were in favor of Alzheimer disease (AD). The present report is the first family study reporting the possible association of OCD and AD. The glutamatergic dysfunction may be a common pathophysiology of OCD and AD explaining this association. Springer-Verlag, 2011 Alzheimer's disease nationallicence Risk factor nationallicence Familial obsessive-compulsive disorder nationallicence Mrabet Khiari Hela Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia aut Achouri Afef Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia aut Ben Ali Nadia Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia aut Cherif Aroua Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia aut Batti Hend Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia aut Messaoud Taieb Laboratoire de Biochimie et Biologie Moléculaire, Hôpital d'Enfants, Tunis, Tunisia aut Mrabet Amel Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia aut Neurological Sciences Springer Milan 32/5(2011-10-01), 959-962 1590-1874 32:5<959 2011 32 10072 https://doi.org/10.1007/s10072-011-0480-0 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0480-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mrabet Khiari Hela Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia aut NATIONALLICENCE 700 1- Achouri Afef Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia aut NATIONALLICENCE 700 1- Ben Ali Nadia Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia aut NATIONALLICENCE 700 1- Cherif Aroua Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia aut NATIONALLICENCE 700 1- Batti Hend Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia aut NATIONALLICENCE 700 1- Messaoud Taieb Laboratoire de Biochimie et Biologie Moléculaire, Hôpital d'Enfants, Tunis, Tunisia aut NATIONALLICENCE 700 1- Mrabet Amel Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/5(2011-10-01), 959-962 1590-1874 32:5<959 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer