caa a22 4500 445357533 CHVBK 20180317142905.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10072-011-0510-y doi (NATIONALLICENCE)springer-10.1007/s10072-011-0510-y Anti-Ma2/Ta antibodies in a woman with primary lateral sclerosis-like phenotype and Sjögren syndrome [Elektronische Daten] [Giovanni Piccolo, Eleonora Tavazzi, Sven Jarius, Enrico Alfonsi, Lorenzo Cavagna, Laura Piccolo, Elisabetta Zardini, Raymond Voltz, Diego Franciotta] Anti-Ma2/Ta antibodies are rare paraneoplastic antibodies, which are mostly associated with limbic encephalitis in male patients with testicular cancer. We report on a 50-year-old woman with a pure progressive spastic paraparesis. Next, she was diagnosed as having a Sjögren syndrome, with serological positivity for anti-SS-Ro antibodies. The patient's serum and cerebrospinal fluid samples were positive for anti-Ma2/Ta antibodies, which were also proved to be intrathecally produced. These findings, and the coexistence of systemic autoimmunity, led us to treat the patient with corticosteroids first, and then with plasma exchange. Neurological symptoms scarcely responded to both the therapies. The search for cancer was negative up to 4years after the disease onset. Our case expands the spectrum of clinical syndromes associated with anti-Ma2/Ta antibodies. Springer-Verlag, 2011 Ma2/Ta onconeural antigen nationallicence Paraneoplastic neurological syndromes nationallicence Primary lateral sclerosis nationallicence Sjögren syndrome nationallicence Piccolo Giovanni Department of Clinical Neurology, IRCCS, National Neurological Institute C. Mondino, Pavia, Italy aut Tavazzi Eleonora Department of Clinical Neurology, IRCCS, National Neurological Institute C. Mondino, Pavia, Italy aut Jarius Sven Division of Molecular Neuroimmunology, Department of Neurology, University of Heidelberg, Heidelberg, Germany aut Alfonsi Enrico Neurophysiology Unit, IRCCS, National Neurological Institute C. Mondino, Pavia, Italy aut Cavagna Lorenzo Division of Rheumatology, IRCCS, Policlinico S. Matteo, Pavia, Italy aut Piccolo Laura Department of Clinical Neurology, IRCCS, National Neurological Institute C. Mondino, Pavia, Italy aut Zardini Elisabetta Laboratory of Neuroimmunology, IRCCS, National Neurological Institute C. Mondino, via Mondino 2, 27100, Pavia, Italy aut Voltz Raymond Department of Palliative Medicine, University Hospital, Cologne, Germany aut Franciotta Diego Laboratory of Neuroimmunology, IRCCS, National Neurological Institute C. Mondino, via Mondino 2, 27100, Pavia, Italy aut Neurological Sciences Springer Milan 32/5(2011-10-01), 915-917 1590-1874 32:5<915 2011 32 10072 https://doi.org/10.1007/s10072-011-0510-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0510-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Piccolo Giovanni Department of Clinical Neurology, IRCCS, National Neurological Institute C. Mondino, Pavia, Italy aut NATIONALLICENCE 700 1- Tavazzi Eleonora Department of Clinical Neurology, IRCCS, National Neurological Institute C. Mondino, Pavia, Italy aut NATIONALLICENCE 700 1- Jarius Sven Division of Molecular Neuroimmunology, Department of Neurology, University of Heidelberg, Heidelberg, Germany aut NATIONALLICENCE 700 1- Alfonsi Enrico Neurophysiology Unit, IRCCS, National Neurological Institute C. Mondino, Pavia, Italy aut NATIONALLICENCE 700 1- Cavagna Lorenzo Division of Rheumatology, IRCCS, Policlinico S. Matteo, Pavia, Italy aut NATIONALLICENCE 700 1- Piccolo Laura Department of Clinical Neurology, IRCCS, National Neurological Institute C. Mondino, Pavia, Italy aut NATIONALLICENCE 700 1- Zardini Elisabetta Laboratory of Neuroimmunology, IRCCS, National Neurological Institute C. Mondino, via Mondino 2, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Voltz Raymond Department of Palliative Medicine, University Hospital, Cologne, Germany aut NATIONALLICENCE 700 1- Franciotta Diego Laboratory of Neuroimmunology, IRCCS, National Neurological Institute C. Mondino, via Mondino 2, 27100, Pavia, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/5(2011-10-01), 915-917 1590-1874 32:5<915 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer