caa a22 4500 445357606 CHVBK 20180317142905.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10072-011-0626-0 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0626-0 Neuropsychological evaluation and follow up in jcv- and non-jcv-related leukoencephalopathies in HIV infection [Elektronische Daten] [C. Zucchella, E. Sinforiani, E. Tavazzi, S. Del Bue, S. Novati, R. Maserati, M. Ceroni, S. Bastianello, L. Minoli, P. Ferrante, E. Marchioni] The introduction of highly active antiretroviral therapy does not seem to have altered the incidence of progressive multifocal leukoencephalopathy (PML) in HIV infection. Moreover, the occurrence of a HIV-related leukoencephalopathy, called not determined leukoencephalopaties (NDLE), has been reported. As neuropsychological impairment remains highly prevalent in HIV infection, the aim of this study is to describe the neuropsychological profile of PML and NDLE patients, analyzing the time-related changes. Clinical and neuropsychological data from 32 patients (17 PML, 15 NDLE) were compared with two control groups: (1) asymptomatic HIV+ patients without magnetic resonance imaging evidence of leukoencephalopathy; (2) age-/gender-/education-matched healthy subjects. Patients with rapidly worsening PML were significantly impaired on all neuropsychological tests, while PML with more benign course and NDLE groups showed a dysexecutive pattern of impairment. Asymptomatic HIV+ subjects showed mild and isolated cognitive deficits, without functional impact. Cognitive impairment should therefore be considered a key feature from HIV infection diagnosis. Springer-Verlag, 2011 HIV infection nationallicence Leukoencephalopathy nationallicence Neuropsychological evaluation nationallicence Highly active antiretroviral therapy nationallicence Zucchella C. Laboratory of Neuropsychology, IRCCS National Neurological Institute C. Mondino Foundation, Via Mondino 2, 27100, Pavia, Italy aut Sinforiani E. Laboratory of Neuropsychology, IRCCS National Neurological Institute C. Mondino Foundation, Via Mondino 2, 27100, Pavia, Italy aut Tavazzi E. Unit of General Neurology, IRCCS National Neurological Institute C. Mondino Foundation, Via Mondino 2, 27100, Pavia, Italy aut Del Bue S. Department of Public Health-Microbiology-Virology, University of Milan, Milan, Italy aut Novati S. Department of Infectious Diseases, "Policlinico S.Matteo”, IRCCS, Viale C. Golgi, 19, 27100, Pavia, Italy aut Maserati R. Department of Infectious Diseases, "Policlinico S.Matteo”, IRCCS, Viale C. Golgi, 19, 27100, Pavia, Italy aut Ceroni M. Unit of General Neurology, IRCCS National Neurological Institute C. Mondino Foundation, Via Mondino 2, 27100, Pavia, Italy aut Bastianello S. Neuroradiology Unit, IRCCS National Neurological Institute C. Mondino Foundation, Via Mondino 2, 27100, Pavia, Italy aut Minoli L. Department of Infectious Diseases, "Policlinico S.Matteo”, IRCCS, Viale C. Golgi, 19, 27100, Pavia, Italy aut Ferrante P. Department of Public Health-Microbiology-Virology, University of Milan, Milan, Italy aut Marchioni E. Unit of General Neurology, IRCCS National Neurological Institute C. Mondino Foundation, Via Mondino 2, 27100, Pavia, Italy aut Neurological Sciences Springer Milan 32/5(2011-10-01), 833-839 1590-1874 32:5<833 2011 32 10072 https://doi.org/10.1007/s10072-011-0626-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0626-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zucchella C. Laboratory of Neuropsychology, IRCCS National Neurological Institute C. Mondino Foundation, Via Mondino 2, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Sinforiani E. Laboratory of Neuropsychology, IRCCS National Neurological Institute C. Mondino Foundation, Via Mondino 2, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Tavazzi E. Unit of General Neurology, IRCCS National Neurological Institute C. Mondino Foundation, Via Mondino 2, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Del Bue S. Department of Public Health-Microbiology-Virology, University of Milan, Milan, Italy aut NATIONALLICENCE 700 1- Novati S. Department of Infectious Diseases, "Policlinico S.Matteo”, IRCCS, Viale C. Golgi, 19, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Maserati R. Department of Infectious Diseases, "Policlinico S.Matteo”, IRCCS, Viale C. Golgi, 19, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Ceroni M. Unit of General Neurology, IRCCS National Neurological Institute C. Mondino Foundation, Via Mondino 2, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Bastianello S. Neuroradiology Unit, IRCCS National Neurological Institute C. Mondino Foundation, Via Mondino 2, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Minoli L. Department of Infectious Diseases, "Policlinico S.Matteo”, IRCCS, Viale C. Golgi, 19, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Ferrante P. Department of Public Health-Microbiology-Virology, University of Milan, Milan, Italy aut NATIONALLICENCE 700 1- Marchioni E. Unit of General Neurology, IRCCS National Neurological Institute C. Mondino Foundation, Via Mondino 2, 27100, Pavia, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/5(2011-10-01), 833-839 1590-1874 32:5<833 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer