caa a22 4500 445357622 CHVBK 20180317142905.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10072-011-0599-z doi (NATIONALLICENCE)springer-10.1007/s10072-011-0599-z Role of TNF-alpha during central sensitization in preclinical studies [Elektronische Daten] [Pablo Andrade, Veerle Visser-Vandewalle, Carolin Hoffmann, Harry Steinbusch, Marc Daemen, Govert Hoogland] Tumor necrosis factor-alpha (TNF-α) is a principal mediator in pro-inflammatory processes that involve necrosis, apoptosis and proliferation. Experimental and clinical evidence demonstrate that peripheral nerve injury results in activation and morphological changes of microglial cells in the spinal cord. These adjustments occur in order to initiate an inflammatory cascade in response to the damage. Between the agents involved in this reaction, TNF-α is recognized as a key player in this process as it not only modulates lesion formation, but also because it is suggested to induce nociceptive signals. Nowadays, even though the function of TNF-α in inflammation and pain production seems to be generally accepted, diverse sources of literature point to different pathways and outcomes. In this review, we systematically searched and reviewed original articles from the past 10years on animal models of peripheral nervous injury describing TNF-α expression in neural tissue and pain behavior. The Author(s), 2011 TNF-α nationallicence Central sensitization nationallicence Neuropathic pain nationallicence Preclinical studies nationallicence Neuroinflammation nationallicence Andrade Pablo Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Universiteitssingel 50, Box 38, 6200 MD, Maastricht, The Netherlands aut Visser-Vandewalle Veerle Department of Neurosurgery, Maastricht University Medical Center, Maastricht, The Netherlands aut Hoffmann Carolin Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Universiteitssingel 50, Box 38, 6200 MD, Maastricht, The Netherlands aut Steinbusch Harry Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Universiteitssingel 50, Box 38, 6200 MD, Maastricht, The Netherlands aut Daemen Marc Department of Neurosurgery, Kliniek Klein Rosendael, Rozendaal, The Netherlands aut Hoogland Govert Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Universiteitssingel 50, Box 38, 6200 MD, Maastricht, The Netherlands aut Neurological Sciences Springer Milan 32/5(2011-10-01), 757-771 1590-1874 32:5<757 2011 32 10072 https://doi.org/10.1007/s10072-011-0599-z text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0599-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Andrade Pablo Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Universiteitssingel 50, Box 38, 6200 MD, Maastricht, The Netherlands aut NATIONALLICENCE 700 1- Visser-Vandewalle Veerle Department of Neurosurgery, Maastricht University Medical Center, Maastricht, The Netherlands aut NATIONALLICENCE 700 1- Hoffmann Carolin Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Universiteitssingel 50, Box 38, 6200 MD, Maastricht, The Netherlands aut NATIONALLICENCE 700 1- Steinbusch Harry Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Universiteitssingel 50, Box 38, 6200 MD, Maastricht, The Netherlands aut NATIONALLICENCE 700 1- Daemen Marc Department of Neurosurgery, Kliniek Klein Rosendael, Rozendaal, The Netherlands aut NATIONALLICENCE 700 1- Hoogland Govert Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Universiteitssingel 50, Box 38, 6200 MD, Maastricht, The Netherlands aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/5(2011-10-01), 757-771 1590-1874 32:5<757 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer