caa a22 4500 445357673 CHVBK 20180317142905.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10072-011-0564-x doi (NATIONALLICENCE)springer-10.1007/s10072-011-0564-x Detection of mumps virus RNA in cerebrospinal fluid of patients with neuromyelitis optica [Elektronische Daten] [Masahiro Mori, Mitsuaki Hosoya, Takaki Hiwasa, Sei Hayakawa, Akiyuki Uzawa, Satoshi Kuwabara] Neuromyelitis optica (NMO) is an acute inflammatory disease that preferentially involves the optic nerves and spinal cord. Although many infectious agents, including mumps virus, are postulated to have a role in the pathogenesis of multiple sclerosis (MS), the relationship between NMO and infectious agents remains uncertain. To investigate the relationship between NMO and viruses that have special affinity for the central nervous system, we performed a nested polymerase chain reaction (PCR) to detect mumps virus or enterovirus RNA in cerebrospinal fluid samples from 13 patients with MS, 8 with NMO and 20 with other neurological diseases (ONDs). Nested PCR was positive for mumps virus in 2 (25%) of NMO patients, but in none of those with MS and ONDs. Moreover, nested PCR results became negative in the remission phase in the two PCR-positive NMO patients. Mumps virus may have some role in the pathogenesis of NMO. Springer-Verlag, 2011 Neuromyelitis optica nationallicence Multiple sclerosis nationallicence Mumps virus nationallicence Infection nationallicence Polymerase chain reaction nationallicence Nested PCR nationallicence Mori Masahiro Departments of Neurology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan aut Hosoya Mitsuaki Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan aut Hiwasa Takaki Department of Biochemistry, Graduate School of Medicine, Chiba University, Chiba, Japan aut Hayakawa Sei Departments of Neurology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan aut Uzawa Akiyuki Departments of Neurology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan aut Kuwabara Satoshi Departments of Neurology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan aut Neurological Sciences Springer Milan 32/5(2011-10-01), 795-799 1590-1874 32:5<795 2011 32 10072 https://doi.org/10.1007/s10072-011-0564-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0564-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mori Masahiro Departments of Neurology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan aut NATIONALLICENCE 700 1- Hosoya Mitsuaki Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan aut NATIONALLICENCE 700 1- Hiwasa Takaki Department of Biochemistry, Graduate School of Medicine, Chiba University, Chiba, Japan aut NATIONALLICENCE 700 1- Hayakawa Sei Departments of Neurology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan aut NATIONALLICENCE 700 1- Uzawa Akiyuki Departments of Neurology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan aut NATIONALLICENCE 700 1- Kuwabara Satoshi Departments of Neurology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/5(2011-10-01), 795-799 1590-1874 32:5<795 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer