caa a22 4500 445357711 CHVBK 20180317142905.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10072-011-0623-3 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0623-3 Bone mineral density in ambulatory patients with multiple sclerosis [Elektronische Daten] [Chrissa Sioka, Stylianos Papakonstantinou, Andreas Fotopoulos, Yiannis Alamanos, Athanasia Georgiou, Sofia Tsouli, Sygliti-Henrietta Pelidou, Athanassios Kyritsis, John Kalef-Ezra] Multiple sclerosis (MS) may be associated with reduced bone mass and higher frequency of osteoporosis. Femoral and spinal bone mineral density (BMD) in 70 ambulatory MS patients (46 females and 24 males) was compared with 100 sex-, age-, and BMI-matched control individuals. BMD was reduced in male patients (lumbar spine 0.976±0.114g/cm2 compared with 1.059±0.147g/cm2 in controls, p=0.024, total hip 0.946±0.136g/cm2 compared to 1.036±0.118g/cm2 in controls, p=0.008, femoral neck 0.812±0.136g/cm2 compared with 0.887±0.135g/cm2 in controls p=0.042), and only in the total hip in female patients (0.88±0.127g/cm2 compared with 0.935±0.112g/cm2 in controls, p=0.018). Multivariate analysis demonstrated that the predominantly affected site was the hip. MS patients exhibit increased frequency of low bone mass compared with controls. Further studies should assess the etiologic factors and employ appropriate therapies. Springer-Verlag, 2011 Osteoporosis nationallicence Osteopenia nationallicence Bone mineral density (BMD) nationallicence Multiple sclerosis (MS) nationallicence Sioka Chrissa Department of Nuclear Medicine, University Hospital of Ioannina, 45110, Ioannina, Greece aut Papakonstantinou Stylianos Department of Neurology, University Hospital of Ioannina, Ioannina, Greece aut Fotopoulos Andreas Department of Nuclear Medicine, University Hospital of Ioannina, 45110, Ioannina, Greece aut Alamanos Yiannis Department of Public Health, University of Patras, Patras, Greece aut Georgiou Athanasia Department of Nuclear Medicine, University Hospital of Ioannina, 45110, Ioannina, Greece aut Tsouli Sofia Department of Neurology, University Hospital of Ioannina, Ioannina, Greece aut Pelidou Sygliti-Henrietta Department of Neurology, University Hospital of Ioannina, Ioannina, Greece aut Kyritsis Athanassios Department of Neurology, University Hospital of Ioannina, Ioannina, Greece aut Kalef-Ezra John Department of Medical Physics, University Hospital of Ioannina, Ioannina, Greece aut Neurological Sciences Springer Milan 32/5(2011-10-01), 819-824 1590-1874 32:5<819 2011 32 10072 https://doi.org/10.1007/s10072-011-0623-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0623-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sioka Chrissa Department of Nuclear Medicine, University Hospital of Ioannina, 45110, Ioannina, Greece aut NATIONALLICENCE 700 1- Papakonstantinou Stylianos Department of Neurology, University Hospital of Ioannina, Ioannina, Greece aut NATIONALLICENCE 700 1- Fotopoulos Andreas Department of Nuclear Medicine, University Hospital of Ioannina, 45110, Ioannina, Greece aut NATIONALLICENCE 700 1- Alamanos Yiannis Department of Public Health, University of Patras, Patras, Greece aut NATIONALLICENCE 700 1- Georgiou Athanasia Department of Nuclear Medicine, University Hospital of Ioannina, 45110, Ioannina, Greece aut NATIONALLICENCE 700 1- Tsouli Sofia Department of Neurology, University Hospital of Ioannina, Ioannina, Greece aut NATIONALLICENCE 700 1- Pelidou Sygliti-Henrietta Department of Neurology, University Hospital of Ioannina, Ioannina, Greece aut NATIONALLICENCE 700 1- Kyritsis Athanassios Department of Neurology, University Hospital of Ioannina, Ioannina, Greece aut NATIONALLICENCE 700 1- Kalef-Ezra John Department of Medical Physics, University Hospital of Ioannina, Ioannina, Greece aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/5(2011-10-01), 819-824 1590-1874 32:5<819 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer