caa a22 4500 445357746 CHVBK 20180317142905.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10072-011-0621-5 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0621-5 Expression of Bcl-2 and Bax after hippocampal ischemia in DHA+EPA treated rats [Elektronische Daten] [Marjan Ajami, Shariar Eghtesadi, Jalaledin Razaz, Naser Kalantari, Rouhollah Habibey, Mohammad Nilforoushzadeh, Mohammadreza Zarrindast, Hamidreza Pazoki-Toroudi] To determine the impact of ω3 fatty acids on post-ischemic expression of pro- and anti-apoptotic proteins in hippocampus, male rats were received 10 or 100mg/kg [Docosahexaenoic acid (DHA)+Ecosapentaenoic acid (EPA); gavage; 21days before ischemia to 2-10days after ischemia]. Global cerebral ischemia reperfusion (IR) was performed using the four-vessel occlusion model; ischemia 8min and reperfusion 6, 48h and 10days. IR increased Bcl-2 and Bax expression after 48h (p<0.05 and p<0.01 vs. sham) and 10days (only Bax; p<0.05), without significant difference with DHA+EPA groups after 6h. But after 48h expression of Bcl-2 increased (p<0.05 vs. IR) and Bax decreased (p<0.05). At day 10 after ischemia expression of Bax in DHA+EPA acid groups was less than IR (p<0.05) and in 100mg/kg DHA+EPA group Bcl-2 expression was more than IR (p<0.05). These data suggested that long-term gavage with DHA+EPA increase hippocampal neurons survival for days after ischemia, revealed by increased Bcl-2 and decreased Bax expressions. Springer-Verlag, 2011 Bcl-2 nationallicence Bax nationallicence Ischemia reperfusion nationallicence Hippocampus nationallicence Omega 3 fatty acid nationallicence Ajami Marjan Department of Nutrition, Tehran University of Medical Sciences, Tehran, Iran aut Eghtesadi Shariar Department of Nutrition, Tehran University of Medical Sciences, Tehran, Iran aut Razaz Jalaledin Nano Medicine and Tissue Engineering Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran aut Kalantari Naser Nano Medicine and Tissue Engineering Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran aut Habibey Rouhollah Physiology Research Center, Tehran University of Medical Sciences, PO BOX 14515-763, Tehran, Iran aut Nilforoushzadeh Mohammad Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran aut Zarrindast Mohammadreza Department of Pharmacology, Tehran University of Medical Science, Tehran, Iran aut Pazoki-Toroudi Hamidreza Physiology Research Center, Tehran University of Medical Sciences, PO BOX 14515-763, Tehran, Iran aut Neurological Sciences Springer Milan 32/5(2011-10-01), 811-818 1590-1874 32:5<811 2011 32 10072 https://doi.org/10.1007/s10072-011-0621-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0621-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ajami Marjan Department of Nutrition, Tehran University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 700 1- Eghtesadi Shariar Department of Nutrition, Tehran University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 700 1- Razaz Jalaledin Nano Medicine and Tissue Engineering Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 700 1- Kalantari Naser Nano Medicine and Tissue Engineering Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 700 1- Habibey Rouhollah Physiology Research Center, Tehran University of Medical Sciences, PO BOX 14515-763, Tehran, Iran aut NATIONALLICENCE 700 1- Nilforoushzadeh Mohammad Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 700 1- Zarrindast Mohammadreza Department of Pharmacology, Tehran University of Medical Science, Tehran, Iran aut NATIONALLICENCE 700 1- Pazoki-Toroudi Hamidreza Physiology Research Center, Tehran University of Medical Sciences, PO BOX 14515-763, Tehran, Iran aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/5(2011-10-01), 811-818 1590-1874 32:5<811 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer