caa a22 4500 445358041 CHVBK 20180317142906.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10072-011-0488-5 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0488-5 Serum uric acid levels in multiple sclerosis patients inversely correlate with disability [Elektronische Daten] [A. Guerrero, F. Gutiérrez, F. Iglesias, J. Martín-Polo, S. Merino, J. Martín-Serradilla, E. Laherrán, M. Tejero] Uric acid (UA) is an endogenous antioxidant. Some studies have described that multiple sclerosis (MS) patients have lower serum UA levels than controls, although it has not been established whether UA is primarily deficient, or secondarily reduced due to its scavenging activity. UA has also been proposed as an indicator of disease activity. We, retrospectively, reviewed 478 serum UA levels obtained in 94 MS patients. Ninety samples were collected during a relapse. Correlation between UA levels obtained during a relapse or in a relapse-free period, and comparison between UA and expanded disability status scale (EDSS) score was tested using a two-tailed Student's t test and Spearman correlation coefficients test. UA levels were significantly lower when measured during a relapse (n 90) than in a remission period (n 368) (r −0.16, p 0.003) UA levels measured outside a relapse inversely correlated with EDSS score (r −0.15, p 0.001). Lower uric acid levels in MS patients are associated with clinical relapse. This is the first description of an inverse correlation of serum UA levels with disability as assessed by EDSS score. Springer-Verlag, 2011 Uric acid nationallicence Multiple sclerosis nationallicence Disability nationallicence Guerrero A. Neurology Unit, Hospital "Río Carrión”, Palencia, Spain aut Gutiérrez F. Neurology Unit, Hospital "Río Carrión”, Palencia, Spain aut Iglesias F. Neurology Unit, Hospital "Río Carrión”, Palencia, Spain aut Martín-Polo J. Neurology Unit, Hospital "Río Carrión”, Palencia, Spain aut Merino S. Neurology Unit, Hospital "Río Carrión”, Palencia, Spain aut Martín-Serradilla J. Neurology Unit, Hospital "Río Carrión”, Palencia, Spain aut Laherrán E. Neurology Unit, Hospital "Río Carrión”, Palencia, Spain aut Tejero M. Neurology Unit, Hospital "Río Carrión”, Palencia, Spain aut Neurological Sciences Springer Milan 32/2(2011-04-01), 347-350 1590-1874 32:2<347 2011 32 10072 https://doi.org/10.1007/s10072-011-0488-5 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0488-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Guerrero A. Neurology Unit, Hospital "Río Carrión”, Palencia, Spain aut NATIONALLICENCE 700 1- Gutiérrez F. Neurology Unit, Hospital "Río Carrión”, Palencia, Spain aut NATIONALLICENCE 700 1- Iglesias F. Neurology Unit, Hospital "Río Carrión”, Palencia, Spain aut NATIONALLICENCE 700 1- Martín-Polo J. Neurology Unit, Hospital "Río Carrión”, Palencia, Spain aut NATIONALLICENCE 700 1- Merino S. Neurology Unit, Hospital "Río Carrión”, Palencia, Spain aut NATIONALLICENCE 700 1- Martín-Serradilla J. Neurology Unit, Hospital "Río Carrión”, Palencia, Spain aut NATIONALLICENCE 700 1- Laherrán E. Neurology Unit, Hospital "Río Carrión”, Palencia, Spain aut NATIONALLICENCE 700 1- Tejero M. Neurology Unit, Hospital "Río Carrión”, Palencia, Spain aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/2(2011-04-01), 347-350 1590-1874 32:2<347 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer