caa a22 4500 445358122 CHVBK 20180317142907.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10072-011-0483-x doi (NATIONALLICENCE)springer-10.1007/s10072-011-0483-x Predictive factors of neutralizing antibodies development in relapsing-remitting multiple sclerosis patients on interferon Beta-1b therapy [Elektronische Daten] [R. Lanzillo, G. Orefice, A. Prinster, G. Ventrella, R. Liuzzi, V. Scarano, C. Florio, G. Vacca, A. Brunetti, B. Alfano, V. Brescia Morra, V. Bonavita] The identification of predictive factors of NAbs development might have a relevant impact on clinical practice. Our objective is to look after predictive factors of NAbs development in MS IFN Beta-1b-treated patients. Database was screened for patients on IFN Beta-1b treatment with an Expanded Disability Status Scale (EDSS) at a baseline between 1 and 3.5, disease duration shorter than 15years, and NAbs analysis performed every 6months. The NAbs positive status was analysed in relation to baseline clinical, neuropsychological and brain imaging measures. Forty-nine patients were included. Sixteen patients had become NAbs positive at some point on IFN therapy (35%). NAbs producers differed from not producers for higher incidence of cognitive deficit and higher lesion load (OR=5.0 and 5.6, respectively). Our study suggests that NAbs development might be a marker of a more aggressive disease and that worse outcome in NAbs producers might be biased by baseline condition. Springer-Verlag, 2011 Multiple sclerosis nationallicence Beta interferon nationallicence Neutralizing antibodies nationallicence Predictive factors nationallicence Cognitive deficit nationallicence Lanzillo R. Department of Neurological Sciences, Federico II University, Via Pansini 5, Naples, Italy aut Orefice G. Department of Neurological Sciences, Federico II University, Via Pansini 5, Naples, Italy aut Prinster A. Biostructure and Bioimaging Institute (IBB), National Council for Research, Via Pansini 5, Naples, Italy aut Ventrella G. Department of Neurological Sciences, Federico II University, Via Pansini 5, Naples, Italy aut Liuzzi R. Biostructure and Bioimaging Institute (IBB), National Council for Research, Via Pansini 5, Naples, Italy aut Scarano V. Department of Neurological Sciences, Federico II University, Via Pansini 5, Naples, Italy aut Florio C. Neurology Unit, AORN Cardarelli, 80131, Naples, Italy aut Vacca G. Department of Neurological Sciences, Federico II University, Via Pansini 5, Naples, Italy aut Brunetti A. Biostructure and Bioimaging Institute (IBB), National Council for Research, Via Pansini 5, Naples, Italy aut Alfano B. Biostructure and Bioimaging Institute (IBB), National Council for Research, Via Pansini 5, Naples, Italy aut Brescia Morra V. Department of Neurological Sciences, Federico II University, Via Pansini 5, Naples, Italy aut Bonavita V. Department of Neurological Sciences, Federico II University, Via Pansini 5, Naples, Italy aut Neurological Sciences Springer Milan 32/2(2011-04-01), 287-292 1590-1874 32:2<287 2011 32 10072 https://doi.org/10.1007/s10072-011-0483-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0483-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lanzillo R. Department of Neurological Sciences, Federico II University, Via Pansini 5, Naples, Italy aut NATIONALLICENCE 700 1- Orefice G. Department of Neurological Sciences, Federico II University, Via Pansini 5, Naples, Italy aut NATIONALLICENCE 700 1- Prinster A. Biostructure and Bioimaging Institute (IBB), National Council for Research, Via Pansini 5, Naples, Italy aut NATIONALLICENCE 700 1- Ventrella G. Department of Neurological Sciences, Federico II University, Via Pansini 5, Naples, Italy aut NATIONALLICENCE 700 1- Liuzzi R. Biostructure and Bioimaging Institute (IBB), National Council for Research, Via Pansini 5, Naples, Italy aut NATIONALLICENCE 700 1- Scarano V. Department of Neurological Sciences, Federico II University, Via Pansini 5, Naples, Italy aut NATIONALLICENCE 700 1- Florio C. Neurology Unit, AORN Cardarelli, 80131, Naples, Italy aut NATIONALLICENCE 700 1- Vacca G. Department of Neurological Sciences, Federico II University, Via Pansini 5, Naples, Italy aut NATIONALLICENCE 700 1- Brunetti A. Biostructure and Bioimaging Institute (IBB), National Council for Research, Via Pansini 5, Naples, Italy aut NATIONALLICENCE 700 1- Alfano B. Biostructure and Bioimaging Institute (IBB), National Council for Research, Via Pansini 5, Naples, Italy aut NATIONALLICENCE 700 1- Brescia Morra V. Department of Neurological Sciences, Federico II University, Via Pansini 5, Naples, Italy aut NATIONALLICENCE 700 1- Bonavita V. Department of Neurological Sciences, Federico II University, Via Pansini 5, Naples, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/2(2011-04-01), 287-292 1590-1874 32:2<287 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer