caa a22 4500 445358270 CHVBK 20180317142907.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10072-010-0463-6 doi (NATIONALLICENCE)springer-10.1007/s10072-010-0463-6 The differentiation of the newborn nerve cells in oculomotor nuclear after oculomotor nerve injury [Elektronische Daten] [Min Yang, Ningxi Zhu, Youqiang Meng, Xuhui Wang, Jun Zhong, Liang Wan, Wenchuan Zhang, Massimiliano Visocchi, Shugan Zhu, Shiting Li] Oculomotor nerve injury is a common complication of cranial trauma and craniotomy. For a long time, it has been generally considered that the oculomotor nerve is unable to regenerate and recover functionally after injury. With the development of neuroradiology, microsurgery and neurohistology, it has been reported that the injured oculomotor nerve could be repaired by operation. However, the mechanisms of neural regeneration of the injured oculomotor nerve remain obscure. Therefore, by investigating the differentiation of the newborn nerve cells in oculomotor nuclear after oculomotor nerve injury, the mechanisms of the neural regeneration of the injured oculomotor nerve was studied in the present paper. After animal model establishment, we found that the function of the injured oculomotor nerve could recover at some degree without treatment, at fourth week after the nerve injury. This result confirms that the injured oculomotor nerve per se has the potential to regenerate and repair. At the present study, by BredU stain, BrdU labeling cells were observed in oculomotor nuclear at the fourth week post-operatively. It indicated that the oculomotor nuclear per se has the ability of generating the cells, which will regenerate and differentiate after the nerve injury, without stimulation by exogenous agents. Immunofluorescence double staining was used in this study to show the differentiation of the newborn cells in oculomotor nuclear after oculomotor nerve injury. It is found that they could differentiate into neural progenitor cells, neuronal cells and neuroglial cells. It is suggested that the different differentiation of cells may play a role in the nerve regeneration procedure. Springer-Verlag, 2011 Oculomotor nerve nationallicence Injury nationallicence Oculomotor nuclear nationallicence Newborn cells nationallicence Differentiation nationallicence Yang Min Department of Neurosurgery, Xinhua Hospital of Shanghai Jiaotong University, No. 1665 Kongjiang Road, 200092, Shanghai, China aut Zhu Ningxi Department of Neurosurgery, The Central Hospital of Taian, 271000, Taian, China aut Meng Youqiang Department of Neurosurgery, Xinhua Hospital of Shanghai Jiaotong University, No. 1665 Kongjiang Road, 200092, Shanghai, China aut Wang Xuhui Department of Neurosurgery, Xinhua Hospital of Shanghai Jiaotong University, No. 1665 Kongjiang Road, 200092, Shanghai, China aut Zhong Jun Department of Neurosurgery, Xinhua Hospital of Shanghai Jiaotong University, No. 1665 Kongjiang Road, 200092, Shanghai, China aut Wan Liang Department of Neurosurgery, Xinhua Hospital of Shanghai Jiaotong University, No. 1665 Kongjiang Road, 200092, Shanghai, China aut Zhang Wenchuan Department of Neurosurgery, Xinhua Hospital of Shanghai Jiaotong University, No. 1665 Kongjiang Road, 200092, Shanghai, China aut Visocchi Massimiliano Institute of Neurosurgery, Catholic University Medical School, Policlinico Gemelli Largo Gemelli, 800168, Rome, Italy aut Zhu Shugan Department of Neurosurgery, Qilu Hospital of Shandong University, 250012, Jinan, China aut Li Shiting Department of Neurosurgery, Xinhua Hospital of Shanghai Jiaotong University, No. 1665 Kongjiang Road, 200092, Shanghai, China aut Neurological Sciences Springer Milan 32/2(2011-04-01), 281-286 1590-1874 32:2<281 2011 32 10072 https://doi.org/10.1007/s10072-010-0463-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-010-0463-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yang Min Department of Neurosurgery, Xinhua Hospital of Shanghai Jiaotong University, No. 1665 Kongjiang Road, 200092, Shanghai, China aut NATIONALLICENCE 700 1- Zhu Ningxi Department of Neurosurgery, The Central Hospital of Taian, 271000, Taian, China aut NATIONALLICENCE 700 1- Meng Youqiang Department of Neurosurgery, Xinhua Hospital of Shanghai Jiaotong University, No. 1665 Kongjiang Road, 200092, Shanghai, China aut NATIONALLICENCE 700 1- Wang Xuhui Department of Neurosurgery, Xinhua Hospital of Shanghai Jiaotong University, No. 1665 Kongjiang Road, 200092, Shanghai, China aut NATIONALLICENCE 700 1- Zhong Jun Department of Neurosurgery, Xinhua Hospital of Shanghai Jiaotong University, No. 1665 Kongjiang Road, 200092, Shanghai, China aut NATIONALLICENCE 700 1- Wan Liang Department of Neurosurgery, Xinhua Hospital of Shanghai Jiaotong University, No. 1665 Kongjiang Road, 200092, Shanghai, China aut NATIONALLICENCE 700 1- Zhang Wenchuan Department of Neurosurgery, Xinhua Hospital of Shanghai Jiaotong University, No. 1665 Kongjiang Road, 200092, Shanghai, China aut NATIONALLICENCE 700 1- Visocchi Massimiliano Institute of Neurosurgery, Catholic University Medical School, Policlinico Gemelli Largo Gemelli, 800168, Rome, Italy aut NATIONALLICENCE 700 1- Zhu Shugan Department of Neurosurgery, Qilu Hospital of Shandong University, 250012, Jinan, China aut NATIONALLICENCE 700 1- Li Shiting Department of Neurosurgery, Xinhua Hospital of Shanghai Jiaotong University, No. 1665 Kongjiang Road, 200092, Shanghai, China aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/2(2011-04-01), 281-286 1590-1874 32:2<281 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer