caa a22 4500 445358297 CHVBK 20180317142907.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10072-010-0422-2 doi (NATIONALLICENCE)springer-10.1007/s10072-010-0422-2 Localization of d -serine and serine racemase in neurons and neuroglias in mouse brain [Elektronische Daten] [Xiaohui Ding, Ning Ma, Masato Nagahama, Kumiko Yamada, Reiji Semba] d-Serine is a novel candidate for an intrinsic ligand for the glycine site of N-methyl-d-aspartate (NMDA) receptors in mammalian brain. d-Serine and serine racemase, which produces d-serine from l-serine, have long been presumed to be localized in astrocytes. However, we have reported that d-serine immunoreactivity was observed in neurons in rats. In the present study, the distributions of d-serine and serine racemase were investigated in combination with marker proteins for neurons, astrocytes and oligodendrocytes in mice. Immunoreactivities for d-serine and serine racemase were found in neurons and oligodendrocytes. These results suggest that d-serine can be produced in neurons as well as glias and used as a neurotransmitter, which control the synaptic function of NMDA receptors. Springer-Verlag, 2010 d -Serine nationallicence Serine nationallicence Racemase nationallicence Neuron nationallicence Neuroglia nationallicence Mouse nationallicence Ding Xiaohui Department of Histology and Embryology, ShenYang Medical College, 110034, ShenYang, People's Republic of China aut Ma Ning Department of Health and Hygiene, Suzuka University of Medical Science, Mie, Japan aut Nagahama Masato Department of Anatomy, Mie University School of Medicine, 514-8507, Tsu, Mie, Japan aut Yamada Kumiko Department of Anatomy, Mie University School of Medicine, 514-8507, Tsu, Mie, Japan aut Semba Reiji Department of Anatomy, Mie University School of Medicine, 514-8507, Tsu, Mie, Japan aut Neurological Sciences Springer Milan 32/2(2011-04-01), 263-267 1590-1874 32:2<263 2011 32 10072 https://doi.org/10.1007/s10072-010-0422-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-010-0422-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ding Xiaohui Department of Histology and Embryology, ShenYang Medical College, 110034, ShenYang, People's Republic of China aut NATIONALLICENCE 700 1- Ma Ning Department of Health and Hygiene, Suzuka University of Medical Science, Mie, Japan aut NATIONALLICENCE 700 1- Nagahama Masato Department of Anatomy, Mie University School of Medicine, 514-8507, Tsu, Mie, Japan aut NATIONALLICENCE 700 1- Yamada Kumiko Department of Anatomy, Mie University School of Medicine, 514-8507, Tsu, Mie, Japan aut NATIONALLICENCE 700 1- Semba Reiji Department of Anatomy, Mie University School of Medicine, 514-8507, Tsu, Mie, Japan aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/2(2011-04-01), 263-267 1590-1874 32:2<263 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer