caa a22 4500 445358327 CHVBK 20180317142907.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s10072-010-0344-z doi (NATIONALLICENCE)springer-10.1007/s10072-010-0344-z Efficacy and tolerability of natalizumab in relapsing-remitting multiple sclerosis patients: a post-marketing observational study [Elektronische Daten] [F. Sangalli, L. Moiola, S. Bucello, P. Annovazzi, A. Rizzo, M. Radaelli, G. Vitello, L. Grimaldi, A. Ghezzi, V. Martinelli, G. Comi] To evaluate the efficacy and safety of natalizumab in patients with active relapsing-remitting multiple sclerosis (MS). We included 285 MS patients receiving natalizumab. Clinical, neuroradiological and safety data were registered every 6months. Neutralizing antibodies (NABs) were tested after 6months of treatment. After 1year, the annualized relapse rate decreased to 0.26, with a significant reduction compared to the previous year (2.13). At 24months the proportion of "relapse free” patients was 78% while that of "MRI free” patients was 69%. Considering clinical and MRI cumulative activity, "disease free” patients were 63% at 24months. A total of 18 patients showed NABs positivity. We reported 34 cases of treatment interruptions. In conclusion, our data confirm the remarkable efficacy of natalizumab in a group of patients with higher disease activity than that of pivotal studies. Springer-Verlag, 2010 Multiple sclerosis nationallicence Natalizumab nationallicence Efficacy nationallicence Safety nationallicence Sangalli F. Department of Neurology, INSPE, IRCCS H San Raffaele, via Olgettina 48, 20132, Milan, Italy aut Moiola L. Department of Neurology, INSPE, IRCCS H San Raffaele, via Olgettina 48, 20132, Milan, Italy aut Bucello S. Department of Neurology, INSPE, IRCCS H San Raffaele, via Olgettina 48, 20132, Milan, Italy aut Annovazzi P. Centro Studi SM, H S. Antonio Abate, Gallarate, VA, Italy aut Rizzo A. Centro Studi SM, H S. Antonio Abate, Gallarate, VA, Italy aut Radaelli M. Department of Neurology, INSPE, IRCCS H San Raffaele, via Olgettina 48, 20132, Milan, Italy aut Vitello G. Ospedale Giglio-HSR, Cefalù, PA, Italy aut Grimaldi L. Ospedale Giglio-HSR, Cefalù, PA, Italy aut Ghezzi A. Centro Studi SM, H S. Antonio Abate, Gallarate, VA, Italy aut Martinelli V. Department of Neurology, INSPE, IRCCS H San Raffaele, via Olgettina 48, 20132, Milan, Italy aut Comi G. Department of Neurology, INSPE, IRCCS H San Raffaele, via Olgettina 48, 20132, Milan, Italy aut Neurological Sciences Springer Milan 31(2011-01-01), 299-302 1590-1874 31<299 2011 31 10072 https://doi.org/10.1007/s10072-010-0344-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-010-0344-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sangalli F. Department of Neurology, INSPE, IRCCS H San Raffaele, via Olgettina 48, 20132, Milan, Italy aut NATIONALLICENCE 700 1- Moiola L. Department of Neurology, INSPE, IRCCS H San Raffaele, via Olgettina 48, 20132, Milan, Italy aut NATIONALLICENCE 700 1- Bucello S. Department of Neurology, INSPE, IRCCS H San Raffaele, via Olgettina 48, 20132, Milan, Italy aut NATIONALLICENCE 700 1- Annovazzi P. Centro Studi SM, H S. Antonio Abate, Gallarate, VA, Italy aut NATIONALLICENCE 700 1- Rizzo A. Centro Studi SM, H S. Antonio Abate, Gallarate, VA, Italy aut NATIONALLICENCE 700 1- Radaelli M. Department of Neurology, INSPE, IRCCS H San Raffaele, via Olgettina 48, 20132, Milan, Italy aut NATIONALLICENCE 700 1- Vitello G. Ospedale Giglio-HSR, Cefalù, PA, Italy aut NATIONALLICENCE 700 1- Grimaldi L. Ospedale Giglio-HSR, Cefalù, PA, Italy aut NATIONALLICENCE 700 1- Ghezzi A. Centro Studi SM, H S. Antonio Abate, Gallarate, VA, Italy aut NATIONALLICENCE 700 1- Martinelli V. Department of Neurology, INSPE, IRCCS H San Raffaele, via Olgettina 48, 20132, Milan, Italy aut NATIONALLICENCE 700 1- Comi G. Department of Neurology, INSPE, IRCCS H San Raffaele, via Olgettina 48, 20132, Milan, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 31(2011-01-01), 299-302 1590-1874 31<299 2011 31 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer