caa a22 4500 445358335 CHVBK 20180317142907.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s10072-010-0382-6 doi (NATIONALLICENCE)springer-10.1007/s10072-010-0382-6 The advent of monoclonal antibodies in the treatment of chronic autoimmune diseases [Elektronische Daten] [Valeria Bruno, Giuseppe Battaglia, Ferdinando Nicoletti] Monoclonal antibodies, first introduced in cancer therapy and to prevent allograft rejection, represent new pharmacological tools for the treatment of autoimmune diseases. With the knowledge of immunological movements in autoimmunity, it is now possible to target each single step of the immune process, from the activation of T lymphocytes in lymph nodes to the formation of the immunological synapse, and to T cell differentiation and cytokine production. However, this approach is still not devoid of adverse effects. In fact, even if monoclonal antibodies exert selective immunomodulation by targeting only cells expressing a specific antigen, a widespread perturbation of the immune system is induced, leading to a predisposition for infections and infestations and to the occurrence of tumours. Springer-Verlag, 2010 Biological drugs nationallicence Monoclonal antibodies nationallicence Autoimmune diseases nationallicence Multiple sclerosis nationallicence Bruno Valeria Department of Physiology and Pharmacology, "Sapienza” University of Rome, Piazzale A. Moro, 5, 00185, Rome, Italy aut Battaglia Giuseppe I.R.C.C.S. Neuromed, Pozzilli, Italy aut Nicoletti Ferdinando Department of Physiology and Pharmacology, "Sapienza” University of Rome, Piazzale A. Moro, 5, 00185, Rome, Italy aut Neurological Sciences Springer Milan 31(2011-01-01), 283-288 1590-1874 31<283 2011 31 10072 https://doi.org/10.1007/s10072-010-0382-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-010-0382-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bruno Valeria Department of Physiology and Pharmacology, "Sapienza” University of Rome, Piazzale A. Moro, 5, 00185, Rome, Italy aut NATIONALLICENCE 700 1- Battaglia Giuseppe I.R.C.C.S. Neuromed, Pozzilli, Italy aut NATIONALLICENCE 700 1- Nicoletti Ferdinando Department of Physiology and Pharmacology, "Sapienza” University of Rome, Piazzale A. Moro, 5, 00185, Rome, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 31(2011-01-01), 283-288 1590-1874 31<283 2011 31 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer