caa a22 4500 445358351 CHVBK 20180317142907.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s10072-010-0346-x doi (NATIONALLICENCE)springer-10.1007/s10072-010-0346-x Natalizumab prevents the accumulation of cortical lesions in relapsing remitting multiple sclerosis: a preliminary report [Elektronische Daten] [F. Rinaldi, M. Calabrese, D. Seppi, M. Puthenparampil, P. Perini, P. Gallo] Natalizumab has been demonstrated to be highly effective in reducing measures of disease activity, such as clinical relapse rate, and gadolinium (Gd)-enhancing and new or enlarging T2 lesions appearance in patients with relapsing remitting multiple sclerosis (RRMS). Up to date, no data on the effect of natalizumab on cortical pathology have been published. We studied the efficacy of natalizumab in preventing the accumulation of new cortical lesions (CL) in 35RRMS patients treated for 1year. While confirming the high impact of natalizumab in reducing the relapse rate (>90%, 85% relapse-free patients) and white matter (WM) pathology (80% patients free from new T2 WM lesions, 97% patients free from new T1 Gd-enhancing lesions), we found that this monoclonal antibody was highly effective in reducing the appearance of new CL (86% patients free from new CL). Our findings indicate a relevant activity of natalizumab against cortical inflammation in RRMS. Springer-Verlag, 2010 Multiple sclerosis nationallicence Natalizumab nationallicence Cortical lesions nationallicence Rinaldi F. Department of Neurosciences, The Multiple Sclerosis Centre of Veneto Region, University Hospital of Padova, Via Giustiniani 5, 35128, Padua, Italy aut Calabrese M. Department of Neurosciences, The Multiple Sclerosis Centre of Veneto Region, University Hospital of Padova, Via Giustiniani 5, 35128, Padua, Italy aut Seppi D. Department of Neurosciences, The Multiple Sclerosis Centre of Veneto Region, University Hospital of Padova, Via Giustiniani 5, 35128, Padua, Italy aut Puthenparampil M. Department of Neurosciences, The Multiple Sclerosis Centre of Veneto Region, University Hospital of Padova, Via Giustiniani 5, 35128, Padua, Italy aut Perini P. Department of Neurosciences, The Multiple Sclerosis Centre of Veneto Region, University Hospital of Padova, Via Giustiniani 5, 35128, Padua, Italy aut Gallo P. Department of Neurosciences, The Multiple Sclerosis Centre of Veneto Region, University Hospital of Padova, Via Giustiniani 5, 35128, Padua, Italy aut Neurological Sciences Springer Milan 31(2011-01-01), 317-320 1590-1874 31<317 2011 31 10072 https://doi.org/10.1007/s10072-010-0346-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-010-0346-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rinaldi F. Department of Neurosciences, The Multiple Sclerosis Centre of Veneto Region, University Hospital of Padova, Via Giustiniani 5, 35128, Padua, Italy aut NATIONALLICENCE 700 1- Calabrese M. Department of Neurosciences, The Multiple Sclerosis Centre of Veneto Region, University Hospital of Padova, Via Giustiniani 5, 35128, Padua, Italy aut NATIONALLICENCE 700 1- Seppi D. Department of Neurosciences, The Multiple Sclerosis Centre of Veneto Region, University Hospital of Padova, Via Giustiniani 5, 35128, Padua, Italy aut NATIONALLICENCE 700 1- Puthenparampil M. Department of Neurosciences, The Multiple Sclerosis Centre of Veneto Region, University Hospital of Padova, Via Giustiniani 5, 35128, Padua, Italy aut NATIONALLICENCE 700 1- Perini P. Department of Neurosciences, The Multiple Sclerosis Centre of Veneto Region, University Hospital of Padova, Via Giustiniani 5, 35128, Padua, Italy aut NATIONALLICENCE 700 1- Gallo P. Department of Neurosciences, The Multiple Sclerosis Centre of Veneto Region, University Hospital of Padova, Via Giustiniani 5, 35128, Padua, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 31(2011-01-01), 317-320 1590-1874 31<317 2011 31 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer