caa a22 4500 445358378 CHVBK 20180317142907.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s10072-010-0351-0 doi (NATIONALLICENCE)springer-10.1007/s10072-010-0351-0 Natalizumab efficacy on cognitive impairment in MS [Elektronische Daten] [F. Mattioli, C. Stampatori, F. Bellomi, R. Capra] We report follow-up data on the efficacy of natalizumab therapy on neuropsychological impairment on an italian MS group of 39 patients at 1year and of 11 patients at 2years. Results show a significant reduction in relapse rate, in the number of impaired neuropsychological tests as well as in several single executive function and reasoning tests scores at 1year. Improvement persisted at 2years, including also memory and speed processing tasks. These data support the efficacy of natalizumab therapy in all the clinical domains, including cognitive deterioration, in multiple sclerosis patients. Springer-Verlag, 2010 Natalizumab nationallicence Cognitive impairment nationallicence Multiple sclerosis nationallicence Mattioli F. Neuropsychology Unit, Spedali Civili of Brescia, Via Nikolajewka, 13, 25123, Brescia, Italy aut Stampatori C. Neuropsychology Unit, Spedali Civili of Brescia, Via Nikolajewka, 13, 25123, Brescia, Italy aut Bellomi F. Neuropsychology Unit, Spedali Civili of Brescia, Via Nikolajewka, 13, 25123, Brescia, Italy aut Capra R. Multiple Sclerosis Center, Spedali Civili of Brescia, Brescia, Italy aut Neurological Sciences Springer Milan 31(2011-01-01), 321-323 1590-1874 31<321 2011 31 10072 https://doi.org/10.1007/s10072-010-0351-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-010-0351-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mattioli F. Neuropsychology Unit, Spedali Civili of Brescia, Via Nikolajewka, 13, 25123, Brescia, Italy aut NATIONALLICENCE 700 1- Stampatori C. Neuropsychology Unit, Spedali Civili of Brescia, Via Nikolajewka, 13, 25123, Brescia, Italy aut NATIONALLICENCE 700 1- Bellomi F. Neuropsychology Unit, Spedali Civili of Brescia, Via Nikolajewka, 13, 25123, Brescia, Italy aut NATIONALLICENCE 700 1- Capra R. Multiple Sclerosis Center, Spedali Civili of Brescia, Brescia, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 31(2011-01-01), 321-323 1590-1874 31<321 2011 31 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer