caa a22 4500 445358394 CHVBK 20180317142907.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s10072-010-0349-7 doi (NATIONALLICENCE)springer-10.1007/s10072-010-0349-7 Improvement of visual acuity in patients with severe visual loss affected by multiple sclerosis treated with natalizumab: a case report [Elektronische Daten] [Ciro Florio, Giorgia Maniscalco] Multiple sclerosis is an important chronic disorders of central nervous system that can lead to severe disability because of the presence of multiple demyelinating lesion. We report a 20-year-old woman with relapsing-remitting MS, with pediatric onset of MS, who developed aggressive disease with visual acuity lost (1/60 in both eyes). Frequent magnetic resonance imaging (MRI) detected persisting inflammatory activity and increase of lesion burden so she was submitted to natalizumab treatment with stability of MRI. After about 10 administrations of natalizumab, she improved her visual acuity in left eye (visual acuity 1/10); visual evocate potential show mild improvement of latency in left eye. Springer-Verlag, 2010 Multiple sclerosis nationallicence Natalizumab nationallicence Florio Ciro Multiple Sclerosis Regional Center, "A. Cardarelli”, Naples, Italy aut Maniscalco Giorgia Multiple Sclerosis Regional Center, "A. Cardarelli”, Naples, Italy aut Neurological Sciences Springer Milan 31(2011-01-01), 325-327 1590-1874 31<325 2011 31 10072 https://doi.org/10.1007/s10072-010-0349-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-010-0349-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Florio Ciro Multiple Sclerosis Regional Center, "A. Cardarelli”, Naples, Italy aut NATIONALLICENCE 700 1- Maniscalco Giorgia Multiple Sclerosis Regional Center, "A. Cardarelli”, Naples, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 31(2011-01-01), 325-327 1590-1874 31<325 2011 31 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer