caa a22 4500 445358408 CHVBK 20180317142908.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s10072-010-0348-8 doi (NATIONALLICENCE)springer-10.1007/s10072-010-0348-8 Natalizumab treatment in multiple sclerosis: the experience of S. Andrea MS Centre in Rome [Elektronische Daten] [L. Prosperini, G. Borriello, F. Fubelli, F. Marinelli, Carlo Pozzilli] We reported a post-marketing experience of 190 patients affected by relapsing multiple sclerosis on treatment with natalizumab. Clinical findings during pre-treatment period and throughout the study were documented. Magnetic resonance imaging (MRI) scans were performed at baseline and at 6, 12, and 24months of therapy. Cumulative proportions of patients disease activity free (i.e. absence of relapses, disability progression, MRI activity) were measured as efficacy endpoints. Despite that the baseline characteristics suggested a more severe course of disease in our sample than that of the AFFIRM trial, data on effectiveness of natalizumab were comparable. At 1year of treatment we found 80 and 70% patients free from relapses and MRI activity, respectively, that is similar to 75 and 62% detected in the AFFIRM trial. Moreover, only 5% of our patients showed a progression of disability after a mean follow-up time of 15months. Finally, the presence of antibodies anti-Natalizumab was strongly related to the occurrence of relapses (p=0.002) and MRI activity (p<0.001) even in the post-marketing experience. Springer-Verlag, 2010 Multiple sclerosis nationallicence Natalizumab nationallicence Post-marketing study nationallicence Prosperini L. Multiple Sclerosis Centre, S. Andrea Hospital, "La Sapienza” University, Via di Grottarossa 1035, 00189, Rome, Italy aut Borriello G. Multiple Sclerosis Centre, S. Andrea Hospital, "La Sapienza” University, Via di Grottarossa 1035, 00189, Rome, Italy aut Fubelli F. Multiple Sclerosis Centre, S. Andrea Hospital, "La Sapienza” University, Via di Grottarossa 1035, 00189, Rome, Italy aut Marinelli F. Multiple Sclerosis Centre, S. Andrea Hospital, "La Sapienza” University, Via di Grottarossa 1035, 00189, Rome, Italy aut Pozzilli Carlo Multiple Sclerosis Centre, S. Andrea Hospital, "La Sapienza” University, Via di Grottarossa 1035, 00189, Rome, Italy aut Neurological Sciences Springer Milan 31(2011-01-01), 303-307 1590-1874 31<303 2011 31 10072 https://doi.org/10.1007/s10072-010-0348-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-010-0348-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Prosperini L. Multiple Sclerosis Centre, S. Andrea Hospital, "La Sapienza” University, Via di Grottarossa 1035, 00189, Rome, Italy aut NATIONALLICENCE 700 1- Borriello G. Multiple Sclerosis Centre, S. Andrea Hospital, "La Sapienza” University, Via di Grottarossa 1035, 00189, Rome, Italy aut NATIONALLICENCE 700 1- Fubelli F. Multiple Sclerosis Centre, S. Andrea Hospital, "La Sapienza” University, Via di Grottarossa 1035, 00189, Rome, Italy aut NATIONALLICENCE 700 1- Marinelli F. Multiple Sclerosis Centre, S. Andrea Hospital, "La Sapienza” University, Via di Grottarossa 1035, 00189, Rome, Italy aut NATIONALLICENCE 700 1- Pozzilli Carlo Multiple Sclerosis Centre, S. Andrea Hospital, "La Sapienza” University, Via di Grottarossa 1035, 00189, Rome, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 31(2011-01-01), 303-307 1590-1874 31<303 2011 31 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer