caa a22 4500 445362421 CHVBK 20180317142919.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10010-011-0148-1 doi (NATIONALLICENCE)springer-10.1007/s10010-011-0148-1 Multi-scale modeling on human intravascular cooling to induce brain hypothermia via circle of Willis [Elektronische Daten] [Xu Xue, Jing Liu] Therapeutic hypothermia has been the most effective therapy to treat serious cardiovascular and cerebrovascular diseases. Among them, intravascular cooling is identified as a most efficient approach to induce brain hypothermia. However until now, some key parameters and temperature management method for intravascular cooling are still not well addressed because of the complexity of human thermoregulation mechanism. Aiming at predicting temperature variation of tissues and organs in a more accurate way during therapeutic hypothermia, this study is dedicated to integrate the blood flow model in the circle of Willis together with the compartmental model for characterizing the heat and blood transport throughout the whole human body. According to the theoretical evaluation, the new model could well simulate the temperature response of the whole human body especially the brain under various cooling. Effects of different intervention site and cooling power to the hypothermia performance are discussed, which shows that carotid artery intervention is a more suitable therapeutic hypothermia method in comparison with femoral artery or femoral vein intervention. These results could help design controlling software for intravascular therapeutic hypothermia device in the near future. Springer-Verlag, 2011 Xue Xu Key Lab of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 100190, Beijing, P.R. China aut Liu Jing Key Lab of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 100190, Beijing, P.R. China aut Forschung im Ingenieurwesen Springer-Verlag 75/4(2011-12-01), 257-269 0015-7899 75:4<257 2011 75 10010 https://doi.org/10.1007/s10010-011-0148-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10010-011-0148-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Xue Xu Key Lab of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 100190, Beijing, P.R. China aut NATIONALLICENCE 700 1- Liu Jing Key Lab of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 100190, Beijing, P.R. China aut NATIONALLICENCE 773 0- Forschung im Ingenieurwesen Springer-Verlag 75/4(2011-12-01), 257-269 0015-7899 75:4<257 2011 75 10010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer