caa a22 4500 445363754 CHVBK 20180317142923.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10397-010-0655-3 doi (NATIONALLICENCE)springer-10.1007/s10397-010-0655-3 Transcervical, intrauterine ultrasound-guided radiofrequency ablation of uterine fibroids with the VizAblate System: safety, tolerability, and ablation results in a closed abdomen setting [Elektronische Daten] [Jose Garza-Leal, David Toub, Iván León, Lorena Saenz, Darrin Uecker, Michael Munrow, Diane King, Jordan Bajor, James Coad] This was a single-site cohort study to evaluate the safety of a new transcervical device (VizAblate™) combining real-time intrauterine sonography with radiofrequency (RF) ablation for the treatment of fibroids. Nineteen women with uterine fibroids received treatment with the VizAblate System in a closed abdomen setting prior to hysterectomy. Twelve of these subjects underwent an immediate abdominal hysterectomy after radiofrequency ablation (acute group), while the remaining seven underwent hysterectomy on post-ablation days16 and 17 (subacute group). Uteri were sectioned and stained with the viability stain triphenyltetrazolium chloride (TTC) to quantify fibroid ablation dimensions and assess the serosa for thermal injury. Subjects in the subacute group were treated with the VizAblate System under conscious sedation; they provided pain and tolerability data for the interval from ablation through hysterectomy, and indicated overall procedural satisfaction. Twenty-two ablations ranging from 1.8 to 36.2cm3 were created among 19 subjects within 20 fibroids and one region of adenomyosis. There were no complications or thermal serosal injury. For subjects in the subacute group receiving one ablation, the mean total procedure time was 25.8 ± 6.0min (range 18-32min). All subjects in the subacute group were discharged within 2h of the VizAblate procedure. For fibroids ≤ 5cm, 67.2% ± 27.0% of the fibroid volume was ablated (range 15-100%; median 75%). Transcervical RF ablation of fibroids under intrauterine sonographic guidance with the VizAblate system can be accomplished with a high degree of reliability and without adverse events. Springer-Verlag, 2011 Radiofrequency ablation nationallicence Fibroids nationallicence Intrauterine sonography nationallicence Myomata nationallicence Garza-Leal Jose Universidad Autónoma de Nuevo León, Monterrey, Nuevo Leon, Mexico aut Toub David Gynesonics, Inc, 604 Fifth Avenue, Suite D, 94063, Redwood City, CA, USA aut León Iván Universidad Autónoma de Nuevo León, Monterrey, Nuevo Leon, Mexico aut Saenz Lorena Universidad Autónoma de Nuevo León, Monterrey, Nuevo Leon, Mexico aut Uecker Darrin Gynesonics, Inc, 604 Fifth Avenue, Suite D, 94063, Redwood City, CA, USA aut Munrow Michael Gynesonics, Inc, 604 Fifth Avenue, Suite D, 94063, Redwood City, CA, USA aut King Diane Gynesonics, Inc, 604 Fifth Avenue, Suite D, 94063, Redwood City, CA, USA aut Bajor Jordan Gynesonics, Inc, 604 Fifth Avenue, Suite D, 94063, Redwood City, CA, USA aut Coad James West Virginia University, Morgantown, WV, USA aut Gynecological Surgery Springer-Verlag 8/3(2011-09-01), 327-334 1613-2076 8:3<327 2011 8 10397 https://doi.org/10.1007/s10397-010-0655-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10397-010-0655-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Garza-Leal Jose Universidad Autónoma de Nuevo León, Monterrey, Nuevo Leon, Mexico aut NATIONALLICENCE 700 1- Toub David Gynesonics, Inc, 604 Fifth Avenue, Suite D, 94063, Redwood City, CA, USA aut NATIONALLICENCE 700 1- León Iván Universidad Autónoma de Nuevo León, Monterrey, Nuevo Leon, Mexico aut NATIONALLICENCE 700 1- Saenz Lorena Universidad Autónoma de Nuevo León, Monterrey, Nuevo Leon, Mexico aut NATIONALLICENCE 700 1- Uecker Darrin Gynesonics, Inc, 604 Fifth Avenue, Suite D, 94063, Redwood City, CA, USA aut NATIONALLICENCE 700 1- Munrow Michael Gynesonics, Inc, 604 Fifth Avenue, Suite D, 94063, Redwood City, CA, USA aut NATIONALLICENCE 700 1- King Diane Gynesonics, Inc, 604 Fifth Avenue, Suite D, 94063, Redwood City, CA, USA aut NATIONALLICENCE 700 1- Bajor Jordan Gynesonics, Inc, 604 Fifth Avenue, Suite D, 94063, Redwood City, CA, USA aut NATIONALLICENCE 700 1- Coad James West Virginia University, Morgantown, WV, USA aut NATIONALLICENCE 773 0- Gynecological Surgery Springer-Verlag 8/3(2011-09-01), 327-334 1613-2076 8:3<327 2011 8 10397 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer