caa a22 4500 445364238 CHVBK 20180317142924.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10397-010-0632-x doi (NATIONALLICENCE)springer-10.1007/s10397-010-0632-x Different approaches for objective scoring of experimental post-operative adhesions in the rat model—a description [Elektronische Daten] [Bernhard Kraemer, Markus Wallwiener, Nina Petri, Hugh Colvin, Sara Brucker, Ralf Rothmund, Taufiek Rajab, Christian Wallwiener] The formation of peritoneal adhesions is an issue for surgical research. Different adhesion-inducing models with subsequent scoring systems are descriptively published. The lack of uniformity is a problem as the reproducibility of experimental adhesion research depends strongly on the employed scoring system. A uniform, widely-used score that seeks to describe this relevant surgical condition would be beneficial for inter-surgeon comparability. We present and contrast six scoring systems after the traumatisation of the parietal peritoneum in the rat model. Advantages, disadvantages and statistical considerations of these systems are highlighted. Experimental adhesions were created bilaterally in n = 11 Wistar rats. This resulted in n = 22 adhesion areas. Standardised trauma was inflicted to the parietal peritoneum in a linear shape (20 × 5mm) using bipolar electrocautery at 40W. The defect was closed using five interrupted 3/0 Vicryl sutures placed equidistantly. After 14days, second look laparotomy was performed and number of adhesions, adhesion coverage, adhesion strength, adhesion quality and the attachment to target organs were scored. A total of 43 adhesions formed at the traumatised areas. All of these adhesions could be scored using the six systems described. The correlation coefficient for adhesion coverage as assessed by a measuring stick versus digital computer analysis of the area was 0.649. Every single scoring approach describes different characteristics of adhesions with non-uniform clinical relevance. A multi-dimensional approach that takes account of statistical considerations is inevitable rather than just the use of limited scoring approaches in the experimental setting. Springer-Verlag, 2010 Peritoneal adhesions nationallicence Scoring system nationallicence Adhesion induction nationallicence Rat model nationallicence Kraemer Bernhard University Hospital for Women, University of Tuebingen, Calwerstr. 7/1, 72076, Tuebingen, Germany aut Wallwiener Markus University Hospital for Women, Heidelberg, Germany aut Petri Nina University Hospital for Women, University of Tuebingen, Calwerstr. 7/1, 72076, Tuebingen, Germany aut Colvin Hugh Addenbrookes Hospital, Cambridge University Hospitals, Cambridge, UK aut Brucker Sara University Hospital for Women, University of Tuebingen, Calwerstr. 7/1, 72076, Tuebingen, Germany aut Rothmund Ralf University Hospital for Women, University of Tuebingen, Calwerstr. 7/1, 72076, Tuebingen, Germany aut Rajab Taufiek Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA aut Wallwiener Christian University Hospital for Women, Technical University of Munich, Munich, Germany aut Gynecological Surgery Springer-Verlag 8/2(2011-05-01), 181-185 1613-2076 8:2<181 2011 8 10397 https://doi.org/10.1007/s10397-010-0632-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10397-010-0632-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kraemer Bernhard University Hospital for Women, University of Tuebingen, Calwerstr. 7/1, 72076, Tuebingen, Germany aut NATIONALLICENCE 700 1- Wallwiener Markus University Hospital for Women, Heidelberg, Germany aut NATIONALLICENCE 700 1- Petri Nina University Hospital for Women, University of Tuebingen, Calwerstr. 7/1, 72076, Tuebingen, Germany aut NATIONALLICENCE 700 1- Colvin Hugh Addenbrookes Hospital, Cambridge University Hospitals, Cambridge, UK aut NATIONALLICENCE 700 1- Brucker Sara University Hospital for Women, University of Tuebingen, Calwerstr. 7/1, 72076, Tuebingen, Germany aut NATIONALLICENCE 700 1- Rothmund Ralf University Hospital for Women, University of Tuebingen, Calwerstr. 7/1, 72076, Tuebingen, Germany aut NATIONALLICENCE 700 1- Rajab Taufiek Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 700 1- Wallwiener Christian University Hospital for Women, Technical University of Munich, Munich, Germany aut NATIONALLICENCE 773 0- Gynecological Surgery Springer-Verlag 8/2(2011-05-01), 181-185 1613-2076 8:2<181 2011 8 10397 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer