caa a22 4500 445364327 CHVBK 20180317142924.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10397-009-0513-3 doi (NATIONALLICENCE)springer-10.1007/s10397-009-0513-3 Carcinosarcoma of the breast: report of a case and review of the literature [Elektronische Daten] [Alexandra Varlatzidou, Aikaterini Mastoraki, Maria Kefala, Panagiotis Safioleas, George Sakorafas, Michael Safioleas] Carcinosarcoma (CS) of the breast is a rare, poorly differentiated, malignant tumor which represents less than 0.1% of all breast cancers. It is strictly defined as a mixed, biphasic neoplasm consisting of a carcinomatous component combined with a malignant nonepithelial element of mesenchymal origin. We present a female patient with breast CS. Relevant literature is briefly reviewed. A 65-year-old-woman was admitted for the management of a palpable mass of the left breast. Mammography depicted a high-density mass with marginal irregularity and pleomorphic calcification. Subsequent excisional biopsy revealed a biphasic metaplastic breast carcinoma, and the patient underwent a left-modified radical mastectomy. The final histopathologic diagnosis was defined as a metaplastic breast carcinoma of CS type, with a squamous cell epithelial component of intermediate and mainly low-grade differentiation. Recent case series describe CS as an uncommon lesion demonstrating an intimate admixture of adenocarcinoma and sarcoma. Current data represent further evidence of the dedifferentiation theory in the origin of CS as it runs a very aggressive course and bears an ominous prognosis. The tumor is characterized by intermingled carcinomatous and sarcomatous areas resembling leaf-like structures of phyllodes pattern. Associated cumulative 5-year survival rate is estimated at 49%. Springer-Verlag, 2009 Breast carcinosarcoma nationallicence Biphasic tumors nationallicence Therapeutic approach nationallicence Literature review nationallicence Varlatzidou Alexandra 4th Department of Surgery, Athens University, Medical School, ATTIKON University Hospital, 1 Rimini str., 12462, Athens, Chaidari, Greece aut Mastoraki Aikaterini 4th Department of Surgery, Athens University, Medical School, ATTIKON University Hospital, 1 Rimini str., 12462, Athens, Chaidari, Greece aut Kefala Maria 4th Department of Surgery, Athens University, Medical School, ATTIKON University Hospital, 1 Rimini str., 12462, Athens, Chaidari, Greece aut Safioleas Panagiotis 4th Department of Surgery, Athens University, Medical School, ATTIKON University Hospital, 1 Rimini str., 12462, Athens, Chaidari, Greece aut Sakorafas George 4th Department of Surgery, Athens University, Medical School, ATTIKON University Hospital, 1 Rimini str., 12462, Athens, Chaidari, Greece aut Safioleas Michael 4th Department of Surgery, Athens University, Medical School, ATTIKON University Hospital, 1 Rimini str., 12462, Athens, Chaidari, Greece aut Gynecological Surgery Springer-Verlag 8/2(2011-05-01), 201-205 1613-2076 8:2<201 2011 8 10397 https://doi.org/10.1007/s10397-009-0513-3 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10397-009-0513-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Varlatzidou Alexandra 4th Department of Surgery, Athens University, Medical School, ATTIKON University Hospital, 1 Rimini str., 12462, Athens, Chaidari, Greece aut NATIONALLICENCE 700 1- Mastoraki Aikaterini 4th Department of Surgery, Athens University, Medical School, ATTIKON University Hospital, 1 Rimini str., 12462, Athens, Chaidari, Greece aut NATIONALLICENCE 700 1- Kefala Maria 4th Department of Surgery, Athens University, Medical School, ATTIKON University Hospital, 1 Rimini str., 12462, Athens, Chaidari, Greece aut NATIONALLICENCE 700 1- Safioleas Panagiotis 4th Department of Surgery, Athens University, Medical School, ATTIKON University Hospital, 1 Rimini str., 12462, Athens, Chaidari, Greece aut NATIONALLICENCE 700 1- Sakorafas George 4th Department of Surgery, Athens University, Medical School, ATTIKON University Hospital, 1 Rimini str., 12462, Athens, Chaidari, Greece aut NATIONALLICENCE 700 1- Safioleas Michael 4th Department of Surgery, Athens University, Medical School, ATTIKON University Hospital, 1 Rimini str., 12462, Athens, Chaidari, Greece aut NATIONALLICENCE 773 0- Gynecological Surgery Springer-Verlag 8/2(2011-05-01), 201-205 1613-2076 8:2<201 2011 8 10397 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer