caa a22 4500 445364467 CHVBK 20180317142925.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10048-010-0254-5 doi (NATIONALLICENCE)springer-10.1007/s10048-010-0254-5 OCT1 polymorphism is associated with response and survival time in anti-Parkinsonian drug users [Elektronische Daten] [Matthijs Becker, Loes Visser, Ron van Schaik, Albert Hofman, André Uitterlinden, Bruno Stricker] Substrates for the Organic Cation Transporter 1, encoded by the SLC22A1 gene, are metformin, amantadine, pramipexole, and, possibly, levodopa. Recently, we identified that the rs622342 A > C polymorphism is associated with the HbA1c lowering effect in metformin users. In the Rotterdam Study, we associated this polymorphism with higher prescribed doses of all anti-Parkinsonian drugs. Between the first and fifth prescriptions for levodopa, for each minor rs622342 C allele, the prescribed doses were 0.34 defined daily dose higher (95% CI 0.064, 0.62; p = 0.017). The mortality ratio after start of levodopa therapy was 1.47 times higher (95% CI 1.01, 2.13; p = 0.045). The Author(s), 2010 Organic Cation Transporter 1 nationallicence Anti-Parkinson Agents nationallicence Pharmacogenetics nationallicence Pharmacoepidemiology nationallicence Becker Matthijs Department of Epidemiology, Erasmus MC, P.O. Box2040, 3000 CA, Rotterdam, The Netherlands aut Visser Loes Department of Epidemiology, Erasmus MC, P.O. Box2040, 3000 CA, Rotterdam, The Netherlands aut van Schaik Ron Department of Clinical Chemistry, Erasmus MC, Rotterdam, The Netherlands aut Hofman Albert Department of Epidemiology, Erasmus MC, P.O. Box2040, 3000 CA, Rotterdam, The Netherlands aut Uitterlinden André Department of Epidemiology, Erasmus MC, P.O. Box2040, 3000 CA, Rotterdam, The Netherlands aut Stricker Bruno Department of Epidemiology, Erasmus MC, P.O. Box2040, 3000 CA, Rotterdam, The Netherlands aut neurogenetics Springer-Verlag 12/1(2011-02-01), 79-82 1364-6745 12:1<79 2011 12 10048 https://doi.org/10.1007/s10048-010-0254-5 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10048-010-0254-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Becker Matthijs Department of Epidemiology, Erasmus MC, P.O. Box2040, 3000 CA, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Visser Loes Department of Epidemiology, Erasmus MC, P.O. Box2040, 3000 CA, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- van Schaik Ron Department of Clinical Chemistry, Erasmus MC, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Hofman Albert Department of Epidemiology, Erasmus MC, P.O. Box2040, 3000 CA, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Uitterlinden André Department of Epidemiology, Erasmus MC, P.O. Box2040, 3000 CA, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Stricker Bruno Department of Epidemiology, Erasmus MC, P.O. Box2040, 3000 CA, Rotterdam, The Netherlands aut NATIONALLICENCE 773 0- neurogenetics Springer-Verlag 12/1(2011-02-01), 79-82 1364-6745 12:1<79 2011 12 10048 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer