caa a22 4500 445364491 CHVBK 20180317142925.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10048-010-0261-6 doi (NATIONALLICENCE)springer-10.1007/s10048-010-0261-6 Evidence for anti-angiogenic and pro-survival functions of the cerebral cavernous malformation protein 3 [Elektronische Daten] [Elisa Schleider, Sonja Stahl, Joycelyn Wüstehube, Ulrich Walter, Andreas Fischer, Ute Felbor] Mutations in CCM1, CCM2, or CCM3 lead to cerebral cavernous malformations, one of the most common hereditary vascular diseases of the brain. Endothelial cells within these lesions are the main disease compartments. Here, we show that adenoviral CCM3 expression inhibits endothelial cell migration, proliferation, and tube formation while downregulation of endogenous CCM3 results in increased formation of tube-like structures. Adenoviral CCM3 expression does not induce apoptosis under normal endothelial cell culture conditions but protects endothelial cells from staurosporine-induced cell death. Tyrosine kinase activity profiling suggests that CCM3 supports PDPK-1/Akt-mediated endothelial cell quiescence and survival. The Author(s), 2010 Cerebral cavernous malformation nationallicence CCM3 nationallicence PDCD10 nationallicence Schleider Elisa Department of Human Genetics, University of Würzburg, Würzburg, Germany aut Stahl Sonja Department of Human Genetics, University of Würzburg, Würzburg, Germany aut Wüstehube Joycelyn Joint Research Division Vascular Biology of the Medical Faculty Mannheim (CBTM), Heidelberg University, Mannheim, Germany aut Walter Ulrich Institute of Clinical Biochemistry and Pathobiochemistry, University of Würzburg, Würzburg, Germany aut Fischer Andreas Joint Research Division Vascular Biology of the Medical Faculty Mannheim (CBTM), Heidelberg University, Mannheim, Germany aut Felbor Ute Institute of Human Genetics, University Hospital Greifswald, Fleischmannstr. 42/44, 17475, Greifswald, Germany aut neurogenetics Springer-Verlag 12/1(2011-02-01), 83-86 1364-6745 12:1<83 2011 12 10048 https://doi.org/10.1007/s10048-010-0261-6 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10048-010-0261-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schleider Elisa Department of Human Genetics, University of Würzburg, Würzburg, Germany aut NATIONALLICENCE 700 1- Stahl Sonja Department of Human Genetics, University of Würzburg, Würzburg, Germany aut NATIONALLICENCE 700 1- Wüstehube Joycelyn Joint Research Division Vascular Biology of the Medical Faculty Mannheim (CBTM), Heidelberg University, Mannheim, Germany aut NATIONALLICENCE 700 1- Walter Ulrich Institute of Clinical Biochemistry and Pathobiochemistry, University of Würzburg, Würzburg, Germany aut NATIONALLICENCE 700 1- Fischer Andreas Joint Research Division Vascular Biology of the Medical Faculty Mannheim (CBTM), Heidelberg University, Mannheim, Germany aut NATIONALLICENCE 700 1- Felbor Ute Institute of Human Genetics, University Hospital Greifswald, Fleischmannstr. 42/44, 17475, Greifswald, Germany aut NATIONALLICENCE 773 0- neurogenetics Springer-Verlag 12/1(2011-02-01), 83-86 1364-6745 12:1<83 2011 12 10048 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer