caa a22 4500 445364580 CHVBK 20180317142926.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10048-011-0289-2 doi (NATIONALLICENCE)springer-10.1007/s10048-011-0289-2 Audiogenic seizure proneness requires the contribution of two susceptibility loci in mice [Elektronische Daten] [M. Jawahar, Carolina Sari, Yvette Wilson, Andrew Lawrence, Thomas Brodnicki, Mark Murphy] Juvenile mice of the DBA/2J strain undergo generalised seizures when exposed to a high-intensity auditory stimulus. Genetic analysis identified three different loci underlying this audiogenic seizure proneness (ASP)—Asp1, Asp2 and Asp3 on chromosomes 12, 4 and 7, respectively. Asp1 is thought to have the strongest influence, and mice with only Asp1 derived from the DBA/2J strain are reported to exhibit ASP. The aim of this study was to characterise more accurately the contributions of the Asp1 and Asp3 loci in ASP using congenic strains. Each congenic strain contains a DBA/2J-derived interval encompassing either Asp1 or Asp3 on a C57BL/6J genetic background. A double congenic C57BL/6J strain containing both Asp loci derived from DBA/2J was also generated. Here, we report that DBA/2J alleles at both of these Asp loci are required to confer ASP because congenic C57BL/6 mice harbouring DBA/2J alleles at only Asp1 or Asp3 do not exhibit ASP, whereas DBA/2J alleles at both loci resulted in increased susceptibility for audiogenic seizure in double congenic C57BL/6 mice. Springer-Verlag, 2011 Audiogenic seizures nationallicence Congenic strains nationallicence Mouse nationallicence Epilepsy nationallicence Jawahar M. Department of Anatomy and Cell Biology, University of Melbourne, 3010, Melbourne, Victoria, Australia aut Sari Carolina Department of Anatomy and Cell Biology, University of Melbourne, 3010, Melbourne, Victoria, Australia aut Wilson Yvette Department of Anatomy and Cell Biology, University of Melbourne, 3010, Melbourne, Victoria, Australia aut Lawrence Andrew Florey Neuroscience Institutes, University of Melbourne, 3010, Melbourne, Victoria, Australia aut Brodnicki Thomas Immunology and Diabetes Unit, St Vincent's Institute, 9 Princes Street, 3065, Fitzroy, Victoria, Australia aut Murphy Mark Department of Anatomy and Cell Biology, University of Melbourne, 3010, Melbourne, Victoria, Australia aut neurogenetics Springer-Verlag 12/3(2011-08-01), 253-257 1364-6745 12:3<253 2011 12 10048 https://doi.org/10.1007/s10048-011-0289-2 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10048-011-0289-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jawahar M. Department of Anatomy and Cell Biology, University of Melbourne, 3010, Melbourne, Victoria, Australia aut NATIONALLICENCE 700 1- Sari Carolina Department of Anatomy and Cell Biology, University of Melbourne, 3010, Melbourne, Victoria, Australia aut NATIONALLICENCE 700 1- Wilson Yvette Department of Anatomy and Cell Biology, University of Melbourne, 3010, Melbourne, Victoria, Australia aut NATIONALLICENCE 700 1- Lawrence Andrew Florey Neuroscience Institutes, University of Melbourne, 3010, Melbourne, Victoria, Australia aut NATIONALLICENCE 700 1- Brodnicki Thomas Immunology and Diabetes Unit, St Vincent's Institute, 9 Princes Street, 3065, Fitzroy, Victoria, Australia aut NATIONALLICENCE 700 1- Murphy Mark Department of Anatomy and Cell Biology, University of Melbourne, 3010, Melbourne, Victoria, Australia aut NATIONALLICENCE 773 0- neurogenetics Springer-Verlag 12/3(2011-08-01), 253-257 1364-6745 12:3<253 2011 12 10048 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer