caa a22 4500 445367229 CHVBK 20180317142934.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00484-010-0339-8 doi (NATIONALLICENCE)springer-10.1007/s00484-010-0339-8 The rate and magnitude of atmospheric pressure change that aggravate pain-related behavior of nerve injured rats [Elektronische Daten] [Megumi Funakubo, Jun Sato, Kouei Obata, Kazue Mizumura] Complaints of patients with chronic pain may increase when the weather changes. The exact mechanism for weather change-induced pain has not been clarified. We have previously demonstrated that artificially lowering barometric pressure (LP) intensifies pain-related behaviors in rats with neuropathic pain [chronic constriction injury (CCI) and spinal nerve ligation (SNL)]. In the present study, we examined the rate and magnitude of LP that aggravates neuropathic pain. We measured pain-related behaviors [number of paw lifts to von Frey hair (VFH) stimulation] in awake rats after SNL or CCI surgery, and found that rates of decompression ≥5hPa/h and ≥10hPa/h and magnitudes of decompression ≥5hPa and ≥10hPa augmented pain-related behaviors in SNL and CCI rats, respectively. These results indicate that LP within the range of natural weather patterns augments neuropathic pain in rats, and that SNL rats are more sensitive to LP than CCI rats. ISB, 2010 Weather-sensitive pain nationallicence Decompression rate nationallicence Decompression magnitude nationallicence Low pressure exposure nationallicence Rats nationallicence Funakubo Megumi Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, 464-8601, Nagoya, Japan aut Sato Jun Futuristic Environmental Simulation Center, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, 464-8601, Nagoya, Japan aut Obata Kouei R & D Department, Environmental Technology Laboratory, Daikin Industries, Ltd., 1304 Kanaoka-cho, Kita-ku, Sakai-shi, 591-8511, Osaka, Japan aut Mizumura Kazue Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, 464-8601, Nagoya, Japan aut International Journal of Biometeorology Springer-Verlag 55/3(2011-05-01), 319-326 0020-7128 55:3<319 2011 55 484 https://doi.org/10.1007/s00484-010-0339-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00484-010-0339-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Funakubo Megumi Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, 464-8601, Nagoya, Japan aut NATIONALLICENCE 700 1- Sato Jun Futuristic Environmental Simulation Center, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, 464-8601, Nagoya, Japan aut NATIONALLICENCE 700 1- Obata Kouei R & D Department, Environmental Technology Laboratory, Daikin Industries, Ltd., 1304 Kanaoka-cho, Kita-ku, Sakai-shi, 591-8511, Osaka, Japan aut NATIONALLICENCE 700 1- Mizumura Kazue Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, 464-8601, Nagoya, Japan aut NATIONALLICENCE 773 0- International Journal of Biometeorology Springer-Verlag 55/3(2011-05-01), 319-326 0020-7128 55:3<319 2011 55 484 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer