caa a22 4500 445367628 CHVBK 20180317142935.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00484-010-0328-y doi (NATIONALLICENCE)springer-10.1007/s00484-010-0328-y Effects of aging on thermoregulatory responses and hormonal changes in humans during the four seasons in Japan [Elektronische Daten] [Maki Sato, Dominika Kanikowska, Junichi Sugenoya, Yoko Inukai, Yuuki Shimizu, Naoki Nishimura, Satoshi Iwase] Physiological functions are impaired in various organs in aged people, as manifest by, e.g., renal and cardiac dysfunction and muscle atrophy. The elderly are also at increased risk of both hypothermia and hyperthermia in extreme temperatures. The majority of those over 65years old have elevated serum osmolality. Our hypothesis is that the elderly have suppressed osmolality control in different seasons compared to the young. Eight healthy young men and six healthy older men participated in this study. The experiments were performed during spring, summer, autumn and winter in Japan, with average atmospheric temperatures of 15-20°C in spring, 25-30°C in summer, 15-23°C in autumn and 5-10°C in winter. Each subject immersed his lower legs in warm water at 40°C for 30min. Core (tympanic) temperature and sweat rate at chest were recorded continuously. Blood was taken pre-immersion to measure the concentrations of antidiuretic hormone, serum osmolality, plasma renin activity, angiotensin II, aldosterone, leptin, thyroid stimulating hormone, fT3 and fT4. The results suggested that the elderly have suppressed osmolality control compared to the young; osmolality was especially elevated in winter compared to the summer in elderly subjects. Therefore, particularly in the elderly, balancing fluid by drinking water should be encouraged to maintain euhydration status in winter. ISB, 2010 Elderly nationallicence Seasonality nationallicence Osmolality nationallicence Antidiuretic hormone nationallicence Sato Maki Department of Physiology, Aichi Medical University, 480-1195, Nagakute, Aichi, Japan aut Kanikowska Dominika Department of Physiology, Aichi Medical University, 480-1195, Nagakute, Aichi, Japan aut Sugenoya Junichi Department of Physiology, Aichi Medical University, 480-1195, Nagakute, Aichi, Japan aut Inukai Yoko Department of Physiology, Aichi Medical University, 480-1195, Nagakute, Aichi, Japan aut Shimizu Yuuki Department of Physiology, Aichi Medical University, 480-1195, Nagakute, Aichi, Japan aut Nishimura Naoki Department of Physiology, Aichi Medical University, 480-1195, Nagakute, Aichi, Japan aut Iwase Satoshi Department of Physiology, Aichi Medical University, 480-1195, Nagakute, Aichi, Japan aut International Journal of Biometeorology Springer-Verlag 55/2(2011-03-01), 229-234 0020-7128 55:2<229 2011 55 484 https://doi.org/10.1007/s00484-010-0328-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00484-010-0328-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sato Maki Department of Physiology, Aichi Medical University, 480-1195, Nagakute, Aichi, Japan aut NATIONALLICENCE 700 1- Kanikowska Dominika Department of Physiology, Aichi Medical University, 480-1195, Nagakute, Aichi, Japan aut NATIONALLICENCE 700 1- Sugenoya Junichi Department of Physiology, Aichi Medical University, 480-1195, Nagakute, Aichi, Japan aut NATIONALLICENCE 700 1- Inukai Yoko Department of Physiology, Aichi Medical University, 480-1195, Nagakute, Aichi, Japan aut NATIONALLICENCE 700 1- Shimizu Yuuki Department of Physiology, Aichi Medical University, 480-1195, Nagakute, Aichi, Japan aut NATIONALLICENCE 700 1- Nishimura Naoki Department of Physiology, Aichi Medical University, 480-1195, Nagakute, Aichi, Japan aut NATIONALLICENCE 700 1- Iwase Satoshi Department of Physiology, Aichi Medical University, 480-1195, Nagakute, Aichi, Japan aut NATIONALLICENCE 773 0- International Journal of Biometeorology Springer-Verlag 55/2(2011-03-01), 229-234 0020-7128 55:2<229 2011 55 484 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer