caa a22 4500 445372974 CHVBK 20180317142953.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00540-010-1058-3 doi (NATIONALLICENCE)springer-10.1007/s00540-010-1058-3 Hypoxic hepatitis in critically ill patients: incidence, etiology and risk factors for mortality [Elektronische Daten] [Joan Raurich, Juan Llompart-Pou, Mireia Ferreruela, Asunción Colomar, Maria Molina, Cristina Royo, Ignacio Ayestarán, Jordi Ibáñez] Purpose: Hypoxic hepatitis may be induced by hemodynamic instability or arterial hypoxemia in critically ill patients. We investigated the incidence, etiology, association with systemic ischemic injury and risk factors for mortality in this population. Methods: Retrospective analysis of patients with hypoxic hepatitis admitted to a multidisciplinary intensive care unit (ICU) of a university hospital. Hypoxic hepatitis was defined as the existence of a compatible clinical setting (cardiocirculatory failure or arterial hypoxemia) and aminotransferase levels higher than 1000IU/L. Results: During the 8-year study period, 182 out of the 7674 patients admitted presented hypoxic hepatitis (2.4%). The most common cause was septic shock. The rate of in-hospital mortality in hypoxic hepatitis was 61.5% (112 patients), and was higher in patients with septic shock (83.3%) and cardiac arrest (77.7%). Ischemic pancreatitis (25.6%), rhabdomyolysis (41.2%) and renal failure (67.2%) were common in these patients. Risk factors of mortality were prolonged INR (p=0.005), need for renal replacement therapy (p=0.001) and septic shock (p=0.005). Conclusions: Hypoxic hepatitis was not a rare condition, and was frequently accompanied by multiorgan injury, with high mortality. Risk factors for increased mortality were prolonged INR, need for renal replacement therapy, and septic shock. Japanese Society of Anesthesiologists, 2010 Hypoxic hepatitis nationallicence Ischemic hepatitis nationallicence Pancreatitis nationallicence Rhabdomyolysis nationallicence Renal failure nationallicence Raurich Joan Servei de Medicina Intensiva, Hospital Universitari Son Dureta, c/ Andrea Doria 55, 07014, Palma de Mallorca, Illes Balears, Spain aut Llompart-Pou Juan Servei de Medicina Intensiva, Hospital Universitari Son Dureta, c/ Andrea Doria 55, 07014, Palma de Mallorca, Illes Balears, Spain aut Ferreruela Mireia Servei de Medicina Intensiva, Hospital Universitari Son Dureta, c/ Andrea Doria 55, 07014, Palma de Mallorca, Illes Balears, Spain aut Colomar Asunción Servei de Medicina Intensiva, Hospital Universitari Son Dureta, c/ Andrea Doria 55, 07014, Palma de Mallorca, Illes Balears, Spain aut Molina Maria Servei de Medicina Intensiva, Hospital Universitari Son Dureta, c/ Andrea Doria 55, 07014, Palma de Mallorca, Illes Balears, Spain aut Royo Cristina Servei de Medicina Intensiva, Hospital Universitari Son Dureta, c/ Andrea Doria 55, 07014, Palma de Mallorca, Illes Balears, Spain aut Ayestarán Ignacio Servei de Medicina Intensiva, Hospital Universitari Son Dureta, c/ Andrea Doria 55, 07014, Palma de Mallorca, Illes Balears, Spain aut Ibáñez Jordi Servei de Medicina Intensiva, Hospital Universitari Son Dureta, c/ Andrea Doria 55, 07014, Palma de Mallorca, Illes Balears, Spain aut Journal of Anesthesia Springer Japan 25/1(2011-02-01), 50-56 0913-8668 25:1<50 2011 25 540 https://doi.org/10.1007/s00540-010-1058-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00540-010-1058-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Raurich Joan Servei de Medicina Intensiva, Hospital Universitari Son Dureta, c/ Andrea Doria 55, 07014, Palma de Mallorca, Illes Balears, Spain aut NATIONALLICENCE 700 1- Llompart-Pou Juan Servei de Medicina Intensiva, Hospital Universitari Son Dureta, c/ Andrea Doria 55, 07014, Palma de Mallorca, Illes Balears, Spain aut NATIONALLICENCE 700 1- Ferreruela Mireia Servei de Medicina Intensiva, Hospital Universitari Son Dureta, c/ Andrea Doria 55, 07014, Palma de Mallorca, Illes Balears, Spain aut NATIONALLICENCE 700 1- Colomar Asunción Servei de Medicina Intensiva, Hospital Universitari Son Dureta, c/ Andrea Doria 55, 07014, Palma de Mallorca, Illes Balears, Spain aut NATIONALLICENCE 700 1- Molina Maria Servei de Medicina Intensiva, Hospital Universitari Son Dureta, c/ Andrea Doria 55, 07014, Palma de Mallorca, Illes Balears, Spain aut NATIONALLICENCE 700 1- Royo Cristina Servei de Medicina Intensiva, Hospital Universitari Son Dureta, c/ Andrea Doria 55, 07014, Palma de Mallorca, Illes Balears, Spain aut NATIONALLICENCE 700 1- Ayestarán Ignacio Servei de Medicina Intensiva, Hospital Universitari Son Dureta, c/ Andrea Doria 55, 07014, Palma de Mallorca, Illes Balears, Spain aut NATIONALLICENCE 700 1- Ibáñez Jordi Servei de Medicina Intensiva, Hospital Universitari Son Dureta, c/ Andrea Doria 55, 07014, Palma de Mallorca, Illes Balears, Spain aut NATIONALLICENCE 773 0- Journal of Anesthesia Springer Japan 25/1(2011-02-01), 50-56 0913-8668 25:1<50 2011 25 540 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer